The effect of an eye mask on midazolam requirement for sedation during spinal anesthesia: a randomized controlled trial

Table 2 Comparison of data between the two groups after midazolam injection

	Masked group (n = 20)	Control group (n = 18)	P-value
Total dose of midazolam administered (mg)	2.8 ± 1.0	3.7 ± 1.3	0.024
Onset time to reach an MOAA/S score = 3 (min)^a	13.8 ± 4.8	18.3 ± 6.4	0.024
Onset time to reach a BIS < 80 (min)^b	12.3 ± 5.5	14.7 ± 6.3	0.264
Time maintaining a BIS < 80 (min)	28.6 ± 16.7	21.4 ± 21.0	0.183
Sedation failure [n (%)]^c	0 (0)	0 (0)	1.000
Incidence of relative hypotension [n (%)]^d	1 (5)	3 (16.7)	0.328
Incidence of relative bradycardia [n (%)]^e	0 (0)	1 (2.6)	0.474
Incidence of apnea [n (%)]^f	2 (10.0)	4 (22.2)	0.395
Score of patient satisfaction with sedation ^g	2.6 ± 0.8	2.6 ± 0.6	0.633

Values are presented as means ± standard deviations
Abbreviations: MOAA/S score modified Observer Assessment of Alertness and Sedation score, BIS bispectral index
^a Time to achieve an MOAA/S score of 3 following midazolam administration
^b Time to reach a BIS < 80 following midazolam administration
^c An MOAA/S score of 3 was not reached when midazolam was administered every 5 min for 35 min
^d Systolic blood pressure decreased by > 20% from baseline (0 min of midazolam administration)
^e Heart rate decrease by > 20% from baseline (0 min of midazolam administration)
^f Repeated interruption of airflow for at least 10 s based on capnography (respiration rate < 6 breaths/min)
^g Very good = 3, good = 2, not bad = 1, bad = 0

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