The erector spinae plane block causes only cutaneous sensory loss on ipsilateral posterior thorax: a prospective observational volunteer study
BMC Anesthesiology volume 20, Article number: 88 (2020)
Ultrasound-guided erector spine plane (ESP) block is widely used in perioperative analgesia for back, chest and abdominal surgery. The extent and distribution of this block remain controversial. This study was performed to assess the analgesia range of an ultrasound-guided ESP block.
This prospective observational volunteer study consisted of 12 healthy volunteers. All volunteers received an erector spinae plane block at the left T5 transverse process using real-time ultrasound guidance. Measured the cutaneous sensory loss area (CSLA) and cutaneous sensory declination area (CSDA) using cold stimulation at different time points after blockade until its disappearance. The CSLA and CSDA were mapped and then calculated. The block range was described by spinous process level and lateral extension. The effective block duration for each volunteer was determined and recorded.
The cold sensory loss concentrates at T6-T9. The decline concentrates primarily at T4-T11. The lateral diffusion of block to the left side did not cross the posterior axillary line, and reached the posterior median line on the right. The area of cutaneous sensory loss was (172 ± 57) cm2, and the area of cutaneous sensory decline was (414 ± 143) cm2. The duration of cutaneous sensory decline was (586 ± 28) minutes.
Ultrasound-guided erector spine plane block with 20 mL of 0. 5% ropivacaine provided a widespread cutaneous sensory block in the posterior thorax, but did not reach the anterior chest, lateral chest, or abdominal walls. The range of the blockade suggested that the dorsal branch of spinal nerve was blocked.
Chinese Clinical Trial Registry, CHiCTR1800014438. Registered 13 January 2018
Forero et al.  first reported the use of an ultrasound-guided ESP block, an interfascial plane block that successfully treats severe thoracic neuropathic pain. In ESP blockade, local anesthetic drugs are injected into the superficial or deep portion of the erector spinae using ultrasound guidance, then through the costotransverse foramina into the region of the spinal nerves and the origins of the dorsal and ventral rami . It is simple, safe, and suitable to perform with an indwelling catheter to prolong postoperative analgesia, it may also prove to have the potential to replace the paravertebral block (PVB) in many clinical situations [2, 3].
Increasing cases of ultrasound-guided erector spinae plane block appeared in clinical applications [4, 5]. At the same time, in order to demonstrate the effect of ultrasound-guided ESP block, many clinical randomized controlled trials (RCT) have been conducted [3, 6,7,8,9,10,11]. Tulgar et al.  confirmed that bilateral ultrasound guided ESP block leads to effective analgesia and reduce analgesia requirement in first 12 h in patients undergoing laparoscopic cholecystectomy (LC). However, Chen et al.  demonstrated that ultrasound-guided multiple-injection PVB provided superior analgesia to intercostal nerve blocks (ICNB) and single-injection ESP block, while ICNB and single-injection ESP block were equally effective in reducing pain after thoracoscopic surgery. It has been reported that single-injection ESP block require more morphine . Recently, a cadaveric study conducted by Aponte et al.  indicated that the dye and contrast agents diffuse in a cephalad-to-caudal direction in the dorsal region of T1-T11, and laterally diffuse to the ribs, as demonstrated by CT scan and anatomical observation. Moreover, no dye or contrast agent was observed to spread to the paravertebral region. Based on the contradiction between clinical trials and cadaveric research reports, it was of importance to perform a volunteer study to determine the range of the ESP block, and to clarify the applicability of the technique.
In this study, ultrasound-guided ESP blocks were performed in healthy volunteers, and the area of blockade was determined by dermal stimulation of cold sensors using ice. The main outcome measured was the range of sensory loss and decline in cutaneous cold sensation, and the secondary outcome measurement was the area of blockade and the duration of decreased cold sensation.
This observational volunteer study was approved by the University’s Institutional Review Board (IRB No.2017–22) and written informed consent was obtained from all subjects participating in the trial. The trial was registered prior to patient enrollment at Chinese Clinical Trial Registry (registration number: CHiCTR1800014438), Principal investigator: Jingxiong Zhang, Date of registration: December 11th, 2017. This study adheres to the applicable CONSORT guidelines.
All 12 volunteers that were enrolled provided written informed consent. The age of volunteers ranged from 25 to 50 years old, and the study was not gender limited. Volunteers required an American society of anesthesiologists (ASA) physical classification system status of I-II, a Body mass index (BMI) of 18.5–28.0 kg/m2, the area of study for cutaneous sensation needed to be intact in order to be confirmed by the cold stimulation test. Exclusion criteria were as follows: allergy to Ropivacaine or other drugs used in this trial, and inability to communicate, ASA grade ≥ 3, BMI less than 18.5 kg/m2 or greater than 28 kg/m2, abnormal platelet function or other coagulopathy, infectious disease of the skin sensation, abnormal skin sensation, spinal deformity, neuropathy, spinal cord disease, torso scar in area studied, and/or a history of abdominal surgery.
Intravenous access was established after the subject was admitted into the designated block ward, and routine monitoring was performed in all participants (noninvasive blood pressure, continuous electrocardiogram, and pulse oximetry). All participants were sedated with 1 to 2 mL of an intravenous mixture of 20 μg/mL fentanyl and 1 mg/mL midazolam.
The volunteer was placed in a sitting position (Fig. 1a). The operator prepared a 80 mm 22G needle (Stimuplex® D; B. Braun Melsungen AG, Melsungen, Germany) and used a 38 mm wide high frequency 6-15MHZ ultrasound probe for high frequency linear sensors (Sonosite X-Porte; Sonosite Inc., Bothell, WA, USA), for block placement.
The apex of the left T5 transverse process (TP) was determined by using a high-frequency ultrasonic probe to identify the fifth rib, and then moved slowly in a medial direction to locate the transverse process. The apex of the T5 TP was identified by using the probe to determine the horizontal and sagittal sections of the T5 TP. The probe was placed in the longitudinal sagittal aspect to find the ultrasound image of the apex of T5 TP, approximately 3 cm lateral to the posterior medial line (Fig. 1b), and then the site was marked.
For the ESP blocks the operative area was disinfected, and the ultrasonic probe was covered with a sterile protective cover, and placed longitudinally at the marked point. The probe was adjusted to identify the three important layers of muscles (from posterior to anterior), i.e., trapezius, rhomboid, and erector spinae, and the optimal point for injection was identified (the apex of the left T5 TP). Local anesthesia with 1% lidocaine was instilled at the site of injection, 1 cm from the probe on the cephalad side. An 80 mm 22 G needle was inserted under ultrasound guidance (in plane), aiming towards the TP. Saline 1-2 ml was injected to determine the gap, and then 20 mL of 0. 5% ropivacaine (Naropin, AstraZeneca AB, Sweden) was injected. Another experienced anesthesiologist and the operator rechecked the needle tip and local anesthetic diffusion in the plane between the erector spinae and the TP with ultrasound (Fig. 1c).
Measurement and calculation
Important landmarks included: the posterior median line, the left scapular line, the left posterior line, the left 12th costal margin line, the left inferior angle of scapular, and the T1 to L4 spines (Fig. 2). For range of distribution measurements, the volunteers were kept in sitting position, and for the remaining time were in the supine position. The patients allowed to leave to urinate and to imbibe water as needed.
The determination of the cutaneous sensory block area was done using cold stimulation (ice cubes) by an attending physician (other than the operator) at 0.5 h, 1 h, and every hour after injection. According to previous experiments, the block lasts for 10 h. Thus, 9 h after the block, we measured every 15 min until cutaneous sensory returns to normal. The time from the end of injection to the last measurement was considered the blockade duration, and was recorded as such. Sensation was evaluated on a 3-point scale: 0 = loss of cold sensation, 1 = decreased cold sensation compared with the sensation at unaffected areas, 2 = normal sensation. The cold stimulus was moved laterally at approximately 2 cm/s from the opposite posterior axillary line at 1 cm intervals and measurements ceased at the left midaxillary line. During application of the cold stimulus, areas of sensory change were marked on the skin, and the marked dots were connected in order to map the blocked area. We marked block levels 1 and 0 with black and red dots, respectively. During the observation period, when the block range was no longer expanding, we connected the black and red dots to map the CSDA and CSLA. Then photos were taken (and saved) (Fig. 3). We covered the CSDA and CSLA with a 37 cm*52 cm transparent rectangular film, and then transferred all surface landmarks/lines to it.
Afterwards, the transferred transparency was converted into a transparent digital-based images with a fixed pixel value (1057*1485) (size: 37 cm*52 cm) using a scanner (Fujitsu FI-7460), and then saved as a JPG format (Fig. 3). After completing the trial, we used the magnetic lasso tool to select the target area that needed to be calculated, and used the histogram toolbar to see/determine the pixel size of the selected area. The actual size of this digital picture was 1924 cm2 [target area pixel / total pixel (fixed pixel)]. We were able to calculate the CSLA and CSDA. The highest and lowest level of spinous processes were observed and recorded.
Any systemic toxicity events regarding local anesthetics, nausea, and vomiting during the block were recorded.
Statistical analysis was performed with SPSS statistical software (version 21.0; SPSS, Chicago, Illinois) using the one-sample Kolmogorov-Smirnov normality test. The demographic data, cutaneous cold sensory area, and cutaneous sensory block duration, were expressed as mean ± SD.
This study involved 12 volunteers, 8 were male. The ages ranged from 27 to 48 years, weight ranged from 62 kg to 79 kg, and height ranged from 158 cm to 177 cm. More details are in Table 1.
Block range of cold cutaneous sensation
The range of sensory loss was maximal at 1 h, with no further expansion. The cold sensory loss was from the T3 spinous process down to the T12 spinous process, and was most concentrated at T6-T9. Except for two volunteers, the lateral diffusion to the left side reached scapular line, did not cross the posterior axillary line; and to the right it reached 1 cm to the left of the posterior median line.
The cold sensory decline was from the T1 spinous process down to the L4 spinous process, and was concentrated at T4-T11. The lateral diffusion to the left side reached scapular line, did not cross the posterior axillary line, and to the right it reached the left of the posterior median line (Figs. 3 and 4).
The average cutaneous sensory block area in the left posterior thorax was (172 ± 57) cm 2, and the decline area was (414 ± 143) cm 2 at 1 h.
The duration of block
The ESP block retarded the cold cutaneous sensation in posterior thorax for 555--645 min, and the duration of sensory decline was (586 ± 28) minutes (Fig. 5).
Side effects and complications
During the operative/block process and subsequent measurement process, the general condition of the patients was very good, and there were no systemic toxicity events regarding local anesthetics, and there was no nausea and vomiting observed.
This is a detailed volunteer study on the blockade range of the ultrasound-guided ESP block. The results of this study suggest that a 20 ml injection of 0.5% ropivacaine in the erector spinae plane administered to the left side of the T5 transverse process results in a significant block of the ipsilateral dorsal cutaneous sensory block. The cold sensory range of declination was from the T1 down to L4 spinous process, with a concentration at T4-T11, and a lateral effect extending between the posterior median and the posterior axillary line. The anterior chest wall, lateral chest wall and abdominal wall were not affected.
The ESP block we applied, was injected the local anesthesia towards the TP, between transverse process and muscle layers. Actually, there are many clinical modifications to ESP block. Cosarcan SK et al.  advanced the needle over the intertransverse ligament, added the injection of local anesthetics above the superior costotransverse ligament (SCTL) to increase the spread into the paravertebral space. Tulgar S et al.  demonstrated different injection points of ESP block, costotransverse block (CTB),and mid-transverse process (MTP) block. It should be emphasized that our method of ESP block does not penetrate the intertransverse ligament. There are many problems with the modified ESP blocks mentioned in the article, such as their nomenclature problem, the problem of ligament recognition under ultrasound , which is contrary to the simplicity and safety of the traditional ESP block. Therefore, we insist on adopting traditional ESP block towards TP, while the modified ESP blocks are still controversial and out of our research scope.
Oksuz et al.  reported that bilateral ESP block after breast reduction is superior to local anesthesia in analgesic drug consumption and pain score. ESP blocks can be used as a suitable, effective and safe method of analgesia after mastectomy. However, Ueshima et al.  reported that an ESP block cannot effectively achieve the full analgesia of T2-T6 anterior branch, and cannot be assumed to provide complete analgesia for breast cancer surgery. Drennen et al.  questioned the pain scores of Oksuz et al.  in that they were higher when compared to previous reports, and questioned the efficacy and use of ESP block in breast reduction surgery without better evidence. Therefore, whether ESP block can produce reliable postoperative analgesia in breast surgery remains uncertain.
A single-center study  concluded that the ESP block and thoracic PVB have similar analgesic effects in patients undergoing open thoracic surgery. The advantage of ESP blocks is that they have a low incidence of adverse reactions. Taketa et al.  suggested that ESP blocks have the properties of a strong lateral cutaneous branch block that are similar to pectoral nerves (PECS) block, but not to PVB or ICNB. Whether ESP blocks can be effectively used in thoracoscopic surgery is still in dispute. Some reports have indicated [6, 11, 18] ESP blocks can be used for abdominal surgery.
Currently most clinical studies support the use of ESP blocks for postoperative analgesia in surgeries involving the posterior thorax, chest, and abdomen. The literature [1, 19, 20] indicates that the specific mechanism of the ESP block involves local anesthetic diffusion in a cephalad-to-caudal direction in the erector spinae plane. It may enter the paravertebral space through the connective tissue complex attached to the transverse process, and then on through the intervertebral foramen. Therein, the ventral and dorsal branches of the spinal nerve are blocked. Gaweda et al.  conducted a RCT study that showed the addition of PECS block to ESP block improved postoperative pain control and increased patient satisfaction. If the mechanism of ESP block is diffusion to the paravertebral space, the results for both groups should be the same. Nuclear magnetic resonance studies by Adhikary et al.  and Schwartzmann et al.  suggested that contrast agents can enter the paravertebral space, and even the epidural space. Further cadaveric studies [22, 23] also suggested that dyes can enter the paravertebral area. However, other studies have raised concerns and objections. Otero PE et al.  according to inject dye in the erector spinae plane in a porcine living model, found there is no evidence of anterior spread of dye involving thoracic paravertebral or epidural spaces. The cadaver study by Ivanusic et al.  also demonstrated that there was no spread of dye anteriorly to the paravertebral space to involve the origins of the ventral and dorsal branches of the thoracic spinal nerves. Therefore, the theory of paravertebral diffusion and intercostal nerve block is not supported. They speculated that the lateral thoracic wall block may be related to the lateral diffusion of local anesthetic drugs affecting the lateral cutaneous branch of the intercostal nerve . Taketa et al.  also confirmed the loss of cold sensation and the disappearance of acupuncture pain when measured at the anterior axillary line and the midclavicular line during an ESP block. Additionally, CT reconstruction by Forero et al.  and the use of nuclear magnetic resonance by Schwartzmann et al.  indicated that contrast media has limited diffusion to the lateral side. Adhikary et al.  made anatomical observations suggesting that in ESP blocks, the dye diffusion was within 10 cm from the posterior median line, thereby not supporting the theory of the lateral spread of local anesthetic drugs. There still remains contradictory evidence regarding paravertebral diffusion in ESP blocks between the different cadaveric studies and medical imaging studies.
Our volunteer trials suggested that ultrasound-guided ESP block only affects the dorsal branch of the ipsilateral spinal nerve. There was no evidence of the block affecting the paravertebral space, intercostal nerve, or lateral branch of the intercostal nerve. Nevertheless, we cannot exclude other anatomical mechanisms, independent of diffusion to the paravertebral space, which could result in the analgesic efficacy of the ESP block observed in clinical practice.
The thoracolumbar fascia, which is a complex structure of several layers that forms a girdle with a sustaining and stabilizing function, seems to contain a high density of nerves and sympathetic fibers . The diffusion of local anesthetic drugs in the thoracolumbar fascia helps to modulate the somatic and visceral pain. Recently, Otero PE et al.  found that the thoracic lymph nodes were stained when exploring the mechanism of ESP block in a porcine model. They considered it might be that the local anesthesia entered the lymphatic reflux and desensitized the sensory nerve fibers connected to the lymphatic finger, contributing to clinical analgesic effects. Regardless of the mechanism, further clinical research is needed to apply ESP block to thoracoabdominal surgery.
However, the ESP block does produce a definite block in the dorsal branch of the spinal nerve, and can be used in pediatric oncological posterior thoracic  and posterior cervical surgery . The future research directions of ESP block use should study the effect of high-thoracic ESP block in scapular surgery and cervical dorsal surgery, and the effect of middle and lower thoracic ESP blocks in thoracic vertebral surgery.
There are several limitations in our study: 1) this is a volunteer study and the sample size is small. There was not a large enough sample size to study drug concentration, capacity, and the effect of the patient’s position on drug diffusion, 2) we only used cold stimulation to measure the cold sensation range. The pain sensitivity and tactile sensation were not measured, and the disappearance and decrease of the cold sensation were biased due to the subjective feelings of the volunteers.3) we didn’t adopt modified ESP blocks, modified ESP blocks may lead to different results.
Ultrasound-guided ESP blocks using 20 mL of 0.5% ropivacaine can provide a widespread cutaneous sensory blockade of posterior chest wall, while sparing the anterior and lateral chest walls, and the abdominal wall. The range of blockade suggested only that the dorsal branch of spinal nerve was blocked.
Availability of data and materials
All data generated or analysed during this study are included in this article.
Erector spinae plane
Cutaneous sensory loss area
Cutaneous sensory declination area
Randomized controlled trial
Intercostal nerve block
American Society of Anesthesiologists
Body mass index
Superior costotransverse ligament
- CTB :
- MTP :
Forero M, Adhikary SD, Lopez H, Tsui C, Chin KJ. The erector Spinae plane block: a novel analgesic technique in thoracic neuropathic pain. Reg Anesth Pain Med. 2016;41(5):621–7.
Forero M, Rajarathinam M, Adhikary S, Chin KJ. Continuous erector Spinae plane block for rescue analgesia in thoracotomy after epidural failure: a case report. A A Case Rep. 2017;8(10):254–6.
Fang B, Wang Z, Huang X. Ultrasound-guided preoperative single-dose erector spinae plane block provides comparable analgesia to thoracic paravertebral block following thoracotomy: a single center randomized controlled double-blind study. Ann Transl Med. 2019;7(8):174.
Chin KJ, Malhas L, Perlas A. The erector Spinae plane block provides visceral abdominal analgesia in bariatric surgery: a report of 3 cases. Reg Anesth Pain Med. 2017;42(3):372–6.
Ueshima H, Otake H. Clinical experiences of ultrasound-guided erector spinae plane block for thoracic vertebra surgery. J Clin Anesth. 2017;38:137.
Tulgar S, Kapakli MS, Senturk O, Selvi O, Serifsoy TE, Ozer Z. Evaluation of ultrasound-guided erector spinae plane block for postoperative analgesia in laparoscopic cholecystectomy: a prospective, randomized, controlled clinical trial. J Clin Anesth. 2018;49:101–6.
Chen N, Qiao Q, Chen R, Xu Q, Zhang Y, Tian Y. The effect of ultrasound-guided intercostal nerve block, single-injection erector spinae plane block and multiple-injection paravertebral block on postoperative analgesia in thoracoscopic surgery: a randomized, double-blinded, clinical trial. J Clin Anesth. 2019;59:106–11.
Altiparmak B, Korkmaz Toker M, Uysal AI, Gumus Demirbilek S. Comparison of the efficacy of erector spinae plane block performed with different concentrations of bupivacaine on postoperative analgesia after mastectomy surgery: ramdomized, prospective, double blinded trial. BMC Anesthesiol. 2019;19(1):31.
Gaweda B, Borys M, Belina B, Bak J, Czuczwar M, Woloszczuk-Gebicka B, Kolowca M, Widenka K. Postoperative pain treatment with erector spinae plane block and pectoralis nerve blocks in patients undergoing mitral/tricuspid valve repair - a randomized controlled trial. BMC Anesthesiol. 2020;20(1):51.
Oksuz G, Bilgen F, Arslan M, Duman Y, Urfalioglu A, Bilal B. Ultrasound-guided bilateral erector Spinae block versus tumescent anesthesia for postoperative analgesia in patients undergoing reduction mammoplasty: a randomized controlled study. Aesthet Plast Surg. 2019;43(2):291–6.
Abu Elyazed MM, Mostafa SF, Abdelghany MS, Eid GM. Ultrasound-guided erector Spinae plane block in patients undergoing open Epigastric hernia repair: a prospective randomized controlled study. Anesth Analg. 2019;129(1):235–40.
Aponte A, Sala-Blanch X, Prats-Galino A, Masdeu J, Moreno LA, Sermeus LA. Anatomical evaluation of the extent of spread in the erector spinae plane block: a cadaveric study. Can J Anaesth. 2019;66(8):886–93.
Cosarcan SK, Dogan AT, Ercelen O, Gurkan Y. Superior costotransverse ligament is the main actor in permeability between the layers? Target-specific modification of erector spinae plane block. Reg Anesth Pain Med 2019.
Tulgar S, Ahiskalioglu A, Thomas DT, Gurkan Y. Should erector spinae plane block applications be standardized or should we revise nomenclature? Reg Anesth Pain Med. 2020;45(4):318–19.
Ueshima H, Otake H. Limitations of the erector Spinae plane (ESP) block for radical mastectomy. J Clin Anesth. 2018;51:97.
Drennen A. Erector spinae block to reduce pain after reduction mammoplasty: we need more evidence. Aesthetic Plast Surg. 2019;43(5):1406–7.
Taketa Y, Irisawa Y, Fujitani T. Ultrasound-guided erector spinae plane block elicits sensory loss around the lateral, but not the parasternal, portion of the thorax. J Clin Anesth. 2018;47:84–5.
Restrepo-Garces CE, Chin KJ, Suarez P, Diaz A. Bilateral continuous erector Spinae plane block contributes to effective postoperative analgesia after major open abdominal surgery: a case report. A A Case Rep. 2017;9(11):319–21.
Chin KJ, Adhikary S, Sarwani N, Forero M. The analgesic efficacy of pre-operative bilateral erector spinae plane (ESP) blocks in patients having ventral hernia repair. Anaesthesia. 2017;72(4):452–60.
Schwartzmann A, Peng P, Maciel MA, Forero M. Mechanism of the erector spinae plane block: insights from a magnetic resonance imaging study. Can J Anaesth. 2018;65(10):1165–6.
Adhikary SD, Pruett A, Forero M, Thiruvenkatarajan V. Erector spinae plane block as an alternative to epidural analgesia for post-operative analgesia following video-assisted thoracoscopic surgery: a case study and a literature review on the spread of local anaesthetic in the erector spinae plane. Ind J Anaesth. 2018;62(1):75–8.
Vidal E, Giménez H, Forero M, Fajardo M. Erector spinae plane block: a cadaver study to determine its mechanism of action. Rev Esp Anestesiol Reanim. 2018;65(9):514–9.
Yang HM, Choi YJ, Kwon HJ, O J, Cho TH, Kim SH. Comparison of injectate spread and nerve involvement between retrolaminar and erector spinae plane blocks in the thoracic region: a cadaveric study. Anaesthesia. 2018;73(10):1244–50.
Otero PE, Fuensalida SE, Russo PC, Verdier N, Blanco C, Portela DA. Mechanism of action of the erector spinae plane block: distribution of dye in a porcine model. Reg Anesth Pain Med. 2020;45(3):198–203.
Ivanusic J, Konishi Y, Barrington MJ. A cadaveric study investigating the mechanism of action of erector Spinae blockade. Reg Anesth Pain Med. 2018;43(6):567–71.
Willard FH, Vleeming A, Schuenke MD, Danneels L, Schleip R. The thoracolumbar fascia: anatomy, function and clinical considerations. J Anat. 2012;221(6):507–36.
Munoz F, Cubillos J, Bonilla AJ, Chin KJ. Erector spinae plane block for postoperative analgesia in pediatric oncological thoracic surgery. Can J Anaesth. 2017;64(8):880–2.
Evans HT, Leslie GJ, Rutka O, Keevil E, Burckett-St Laurent D. Bilateral erector Spinae plane block for surgery on the posterior aspect of the neck: a case report. A A Pract. 2019;12(10):356–8.
This work was supported by the National Natural Science Foundation of China, Beijing, China (grant no: 81670219). The fund provided support in experimental design, implementation, data analysis, and interpretation of data and in writing the manuscript.
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The study was approved by Ethics Committee of the First Affiliated Hospital of Wenzhou Medical University. All participates provided written informed consent.
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Zhang, J., He, Y., Wang, S. et al. The erector spinae plane block causes only cutaneous sensory loss on ipsilateral posterior thorax: a prospective observational volunteer study. BMC Anesthesiol 20, 88 (2020). https://doi.org/10.1186/s12871-020-01002-0