Table 1 Perioperative characteristics of patients scheduled for on-pump cardiac surgery
Characteristics | PAI-1 -844 A/G | ACE Intron 16 I/D | ||||
|---|---|---|---|---|---|---|
Genotype | G/G | A/G | A/A | I/I | I/D | D/D |
Number of patients, n | 22 | 387 | 23 | 22 | 42 | 19 |
Demographic data | ||||||
 Age, yr | 61 ± 11 | 68 ± 10 | 67 ± 11 | 68 ± 10 | 66 ± 10 | 63 ± 14 |
 Male sex, n (%) | 15 (68) | 16 (42) | 11 (48) | 9 (41)* | 23 (55)* ** | 10 (53)** |
 BMI, kg/m2 | 28 ± 5 | 28 ± 8 | 27 ± 5 | 27 ± 5 | 28 ± 5 | 27 ± 4 |
 EF, (%) | 57 ± 8 | 55 ± 8 | 56 ± 7 | 58 ± 6 | 55 ± 9 | 55 ± 7 |
Type of surgery, n (%) | ||||||
 CABG, n (%) | 11 (50) | 15 (40) | 8 (35) | 8 (36) | 18 (43) | 8 (42) |
 Valve, n (%) | 8 (36) | 13 (34) | 10 (43) | 9 (41) | 13 (31) | 9 (47) |
 Mixed, n (%) | 3 (14) | 10 (26) | 5 (22) | 5 (23)* | 11 (26)* ** | 2(11)** |
Surgical variables | ||||||
 CPB duration (min) | 110 ± 42 | 106 ± 42 | 99 ± 37 | 101 ± 47 | 105 ± 39 | 109 ± 37 |
 Aorta oclusion time (min) | 69 ± 30 | 65 ± 25 | 63 ± 11 | 64 ± 27 | 65 ± 27 | 69 ± 29 |
 Reperfusion time (min) | 33 ± 12 | 33 ± 15 | 33 ± 16 | 29 ± 13 | 36 ± 17 | 33 ± 9 |
 CPB priming volume, ml | 1864 ± 543 | 1509 ± 516 | 1329 ± 440 | 1379 ± 462 | 1548 ± 556 | 1544 ± 482 |
 Cardioplegia, ml | 1872 ± 587 | 1673 ± 516 | 1886 ± 674 | 1647 ± 523 | 1833 ± 655 | 1836 ± 478 |
Preoperative parameters | ||||||
 Hemoglobin, g/dL | 136 ± 15 | 139 ± 13 | 131 ± 18 | 132 ± 17 | 137 ± 16 | 138 ± 12 |
 Platelet count, × 109/L | 221 ± 67 | 215 ± 50 | 215 ± 63 | 211 ± 45 | 218 ± 65 | 220 ± 58 |
 Prothrombin time, % | 84 ± 15 | 90 ± 14 | 92 ± 12 | 94 ± 15 | 89 ± 13 | 85 ± 14 |
 Fibrinogen, g/L | 4.4 ± 1.3 | 4.6 ± 1.2 | 4.7 ± 1.5 | 4.5 ± 1.2 | 4.6 ± 1.2 | 4.7 ± 3.7 |