This article has Open Peer Review reports available.
Severe upper airway obstruction due to delayed retropharyngeal hematoma formation following blunt cervical trauma
© Lazott et al; licensee BioMed Central Ltd. 2007
Received: 08 August 2006
Accepted: 12 March 2007
Published: 12 March 2007
We report a case of severe upper airway obstruction due to a retropharyngeal hematoma that presented nearly one day after a precipitating traumatic injury. Retropharyngeal hematomas are rare, but may cause life-threatening airway compromise.
A 50 year-old man developed severe dyspnea with oropharyngeal airway compression due to retropharyngeal hematoma 20 hours after presenting to the emergency department. The patient also had a fractured first cervical vertebra and was diagnosed with a left brachial plexopathy. The patient underwent emergent awake fiberoptic endotracheal intubation to provide a definitive airway.
Retropharyngeal hematoma with life-threatening airway compromise can develop hours or days after a precipitating injury. Clinicians should be alert to the potential for this delayed airway collapse, and should also be prepared to rapidly secure the airway in this patient population likely to have concomitant cervical spinal or head injuries.
Retropharyngeal hematomas large enough to cause severe upper airway obstruction and respiratory distress are rare. Hematoma development and symptom onset may be delayed from an injury and as a result, initial diagnostic radiographic studies may be unremarkable. Treatment in the dyspneic patient should include immediate stabilization of the airway because initial symptoms may progress rapidly to severe upper airway obstruction and death. We describe a patient who developed a retropharyngeal hematoma that caused acute airway compromise 20 hours after presenting to the emergency department with a fracture of the first cervical vertebra. The rationale for our management strategy utilizing an awake fiberoptic intubation technique is also detailed.
The patient was treated with oxygen at the MRI suite while members of both the surgery and anesthesiology department were contacted for emergent management. Upon their arrival, the patient had a blood pressure of 150/80 mmHg, pulse of 66 beats per minute, a 99% oxygen saturation level, respiratory rate of 24 breaths per minute, and appeared in mild distress. He was immediately transported to the intensive care unit by the physician team for definitive airway control. The patient was prepared for awake nasal fiberoptic intubation with intravenous glycopyrrolate and lidocaine spray topically to the nasopharynx. The bronchoscope was passed through the nasopharynx, vocal cords, and into the trachea. The pharynx and superior trachea were severely distorted and compressed. A 7.0 mm endotracheal tube was passed over the bronchoscope and positioned approximately 3 cm above the carina. The patient was comfortable and did not move during the procedure. Cervical spine immobilization was maintained throughout. Additionally, a surgeon and instruments were present throughout the procedure in anticipation of emergent tracheostomy if fiberoptic intubation were unsuccessful. After intubation, the patient was sedated and mechanically ventilated.
The retropharyngeal space is a potential space that lies posterior to the buccopharyngeal fascia surrounding the pharynx, anterior to the prevertebral fascia of the cervical and thoracic spine and extends laterally to the carotid sheaths. It begins at the base of the skull and terminates in the superior mediastinum [1, 2]. The mechanisms triggering hemorrhage into the retropharyngeal space are thought to include injury to the longus colli muscles on the anterior surface of the vertebral bodies, the anterior longitudinal ligament or the anterior muscular and spinal branches of the vertebral arteries [2–5]. These injuries are most commonly associated with closed cervical neck trauma  and anticoagulant therapy , but they have also been attributed to blunt head trauma, bleeding diathesis, cannulation of the internal jugular vein, arteriography, whiplash injury, foreign body ingestion, retropharyngeal infection, carotid artery aneurysm, carotid sinus massage, metastatic disease and can even occur spontaneously [6–8].
As blood enters the retropharyngeal space, the expanding hematoma can cause tracheal compression, which may rapidly progress to acute airway obstruction [1, 3]. The incidence of airway obstruction resulting from retropharyngeal hematomas is low, but its occurrence can be life threatening [2, 4, 7].
Patients classically present with "Capp's Triad" which includes compression of the trachea and esophagus, displacement of the trachea anteriorly and bruising of the neck and chest . Our patient had minimal bruising, but did demonstrate tracheal compression and displacement. The initial symptoms of airway compression may include dyspnea, dysphagia, stridor, odynophagia, hoarseness and neck pain [6, 9]. Patients whose symptoms are suggestive of retropharyngeal hematomas warrant close and often prolonged follow-up because, as with our patient, a delay can exist between the patient's initial injury or symptoms and the development of respiratory distress . Although most patients become symptomatic immediately or within hours of the development of the hematoma, there have been reports of patients who experienced airway obstruction as long as 5 days after developing the initial symptoms of airway compression [4, 6]. Clinicians should maintain a high degree of suspicion when evaluating patients presenting with symptoms of airway compression whose mechanism of injury is consistent with those associated with retropharyngeal hematomas because these initial symptoms may progress rapidly to lethal airway obstruction. In particular, dyspnea should be considered a key clinical indicator of a possible airway crisis because significant airway compression must occur prior to a healthy patient reporting a dyspneic sensation .
Although treatment course may vary depending on the etiology of the hematoma, the first step in management is establishing definitive airway control . If no airway compromise is present and the patient has a small, stable hematoma, conservative management and observation are indicated. These patients should be followed radiographically to ensure complete resolution of the hematoma [4, 5]. Patients with airway compromise, however, should be managed aggressively utilizing a multidisciplinary approach including an experienced anesthesiologist and surgeon prepared to perform emergent tracheostomy if indicated. Careful attention should be directed towards any associated spinal injuries which may complicate airway management, making a difficult intubation even more challenging.
We chose an awake nasal fiberoptic intubation technique to secure our patient's airway. This avoided the risk of airway collapse resulting from traditional intravenous induction agents, although ketamine, coupled with an antisialogogue, would have been a viable alternative because it exerts minimal effects on muscular airway tone . Furthermore, this approach allowed direct visualization of the patient's airway anatomy with negligible manipulation of the hematoma [1, 5]. We were careful to limit our manipulation as much as possible, for fear of hematoma rupture with resultant bleeding and worsening airway compromise . The fiberoptic approach allowed us to maintain cervical spine alignment during intubation minimizing risk of further spinal injury.
Retropharyngeal hematoma is a rare disease, but may develop distant from a presenting injury and in the setting of normal coagulation and platelet function. Resultant dyspnea is an ominous sign of impending respiratory collapse and requires promptly securing the airway. Concomitant spinal injuries should be sought and when present, may further complicate attempts at airway management. We encourage close and prolonged follow up both clinically and radiographically of these patients, and would consider sequential CT scans in high risk groups. We advocate awake fiberoptic intubation with surgical backup as an optimal approach for managing these patients.
We appreciate the patient's consent to publish this report. Only routine departmental funding supported this project.
- Williams S: Airway management for a retropharyngeal hematoma. J of Emerg Med. 1995, 13: 243-244. 10.1016/S0736-4679(99)80011-0.View ArticleGoogle Scholar
- Tenofsky P, Porter S, Shaw J: Fatal airway compromise due to retropharyngeal hematoma after airbag deployment. Am Surg. 2000, 66: 692-694.PubMedGoogle Scholar
- Shiratori T, Hara K, Ando N: Acute airway obstruction secondary to retropharyngeal hematoma. J Anesth. 2003, 17: 46-48. 10.1007/s005400300007.View ArticlePubMedGoogle Scholar
- El Kettani C, Badaoui R, Lesoin FX, Le Gars D, Ossart M: Traumatic retropharyngeal hematoma necessitating emergency intubation. Anesthesiology. 2002, 97: 1645-1646. 10.1097/00000542-200212000-00049.View ArticlePubMedGoogle Scholar
- Tsai K, Huang YC: Traumatic retropharyngeal hematoma: case report. J Trauma. 1999, 46: 715-716.View ArticlePubMedGoogle Scholar
- Senthuran S, Lim S, Gunning KE: Life-threatening airway obstruction caused by a retropharyngeal haematoma. Anaesthesia. 1999, 54: 670-682. 10.1046/j.1365-2044.1999.00890.x.View ArticleGoogle Scholar
- Sandooram D, Chandramohan AR, Radcliffe G: Retropharyngeal haematoma causing airway obstruction: A multidisciplinary challenge. J Laryngol Otol. 2000, 114: 706-708. 10.1258/0022215001906552.View ArticlePubMedGoogle Scholar
- Munoz A, Fischbein N, de Vergas J, Crespo J, Alvarez-vincent J: Spontaneous retropharyngeal hematoma: Diagnosis by MR imaging. Am J Neuroradiol. 2001, 22: 1209-1211.PubMedGoogle Scholar
- Suzuki T, Imai H, Uchino M, Wakita R, Endo M, Kitahara T, Soma K, Ohwada T: Fatal retropharyngeal haematoma secondary to blunt trauma. Injury. 2004, 35: 1059-1063. 10.1016/j.injury.2003.11.013.View ArticlePubMedGoogle Scholar
- Drummond GB: Comparison of sedation with midazolam and ketamine: effects on airway muscle activity. Br J Anaesth. 1996, 76: 663-667.View ArticlePubMedGoogle Scholar
- The pre-publication history for this paper can be accessed here:http://www.biomedcentral.com/1471-2253/7/2/prepub
This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.