Table 4 Differences between Lacassie 2013 and Tseng 2018

Interventions

General anesthesia combined with epidural anesthesia used intraoperatively or postoperatively

Medications

0.1–0.5% bupivacaine with or without opioids

0.05% bupivacaine, with or without opioids

Duration

At least 48 h

Up to 14 days

Proportion

/

intraoperatively VS postoperatively: 89% VS 11%

Outcomes

OS:HR 0.74(95%CI 0.36, 1.49)

TTR:HR 0.73(95%CI 0.40, 1.31)

OS:HR 0.63(95%CI 0.49, 0.82)

TTR:HR 0.75(95%CI 0.61,0.93)

Study populations

Stage IIIC and IV

Stage IIIB and IV