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Table 4 Postoperative outcomes

From: Myocardial protection with phosphocreatine in high-risk cardiac surgery patients: a randomized trial

 

Placebo (n = 63)

Phosphocreatine (n = 57)

p-value

Number of patients requiring vasopressor/inotropic drugs, n (%)

57 (91%)

49 (88%)

0.60

LVEF on POD 1, %—median (IQR)

56 (50–62)

55 (52–59)

0.89

Inotropic score on POD 1—median (IQR)

4 (0–10)

4 (0–7)

0.47

SOFA score on POD 1 – mean ± SD

5.45 ± 2.65

5.25 ± 2.33

0.83

Mechanical ventilation, hours

6 (4–10)

6 (4–11)

0.70

New onset atrial fibrillation, n (%)

5/43 (12%)

8/30 (27%)

0.13

Duration of ICU stay, hours—median (IQR)

17 (16–20)

18 (16–20)

0.58

Length of hospitalization, days—median (IQR)

14 (11–16)

13 (11–15)

0.64

Myocardial infarction, n (%)

2 (3.2%)

2 (3.5%)

0.92

Acute kidney injury, n (%)

6 (9.5%)

9 (16%)

0.43

Neurological damage type I, n (%)

0 (0%)

1 (1.7%)

0.29

Neurological damage type II, n (%)

4 (6.3%)

5 (8.8%)

0.61

Mediastinitis, n (%)

3 (4.8%)

1 (1.7%)

0.36

Wound infection, n (%)

2 (3.2%)

2 (3.5%)

0.92

Pneumonia, n (%)

2 (3.2%)

2 (3.5%)

0.92

30-day mortality, n (%)

1 (4.3%)

0 (0%)

0.40

  1. Abbreviations: IQR Inter Quartile Range (25th-75th percentiles), LVEF Left Ventricular Ejection Fraction, POD Post Operative Day, SD Standard Deviation, SOFA Sequential Organ Failure Assessment, ICU Intensive Care Unit