Fig. 5

THC effect on pial arteriole diameter in female rats is influenced by anesthetics. A Averaged fold-change in female pial arteriole diameter as a function of time following carotid artery infusion of DMSO-containing saline under KX anesthesia (n = 4) or 42 nM THC under KX (n = 5). B Averaged fold-change in female pial arteriole diameter as a function of time following carotid artery infusion of DMSO-containing saline under isoflurane (n = 4), and 42 nM THC under isoflurane (n = 4). Here and in C, tr: statistical trend with 0.05 ≤ p ≤ 0.10 by 1-tail Mann–Whitney test. C Scattered graph comparing THC effect on female pial cerebral arteriole diameter under KX versus isoflurane anesthesia. Each datapoint within each group was normalized to averaged effect of DMSO-containing saline at the same time-point within respective group. Asterisks depict statistically significant differences with 0.0079 ≤ p ≤ 0.0317 by 1-tail Mann–Whitney test