Fig. 3

Alcohol effect on pial arteriole diameter under different anesthetics in female rats. A Averaged fold-change in female pial arteriole diameter as a function of time following carotid artery infusion of 0.9% NaCl (saline) under KX anesthesia (n = 4) or 50 mM EtOH under KX (n = 4). Here and in B, representative cranial window images from female rats showing lack of vasoconstriction by 50 mM EtOH disregard the type of anesthetic used. B Averaged fold-change in female pial arteriole diameter as a function of time following carotid artery infusion of 0.9% NaCl under isoflurane (n = 4), and 50 mM EtOH under isoflurane (n = 4). C Scattered graph showing lack of EtOH-induced constriction in female pial cerebral arterioles under KX or isoflurane anesthesia. Each datapoint within each group was normalized to averaged effect of 0.9% NaCl at the same time-point within respective group