Fig. 5

The role of MAOA in sepsis rats. A Volcano plot of differentially-expressed genes (DEGs) of GSE57065. Statistically significant DEGs were identified as those with a student’s t-test (|logFC|> 1, P < 0.001). B Representative Western blotting images and (C) quantification of Western blotting results of MAOA between the control group, the sepsis group and the RS-8359 group in heart tissues (n = 3 independent experiments). ***P < 0.001 vs control, ###P < 0.001 vs sepsis. D The level of phenylalanine in heart tissues detected by the phenylalanine assay kit (ab241000, Abcam) (n = 6 each group). ***P < 0.001 vs control, #P < 0.05 vs sepsis. (E) MAP within 6 h detecting starting at 12 h after CLP between the control group, the sepsis group and the RS-8359 group (n = 8 each group). ***P < 0.001 vs control, ###P < 0.001 vs sepsis. F The survival rate of rats between the control group, the sepsis group and the RS-8359 group (n = 16 each group). **P < 0.01 vs control, #P < 0.05 vs sepsis. G The survival time of rats in between the control group, the sepsis group and the RS-8359 group. **P < 0.01 vs control, #P < 0.05 vs sepsis