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Table 2 The overall results of GRADE evaluation

From: Effects of xenon anesthesia on postoperative neurocognitive disorders: a systematic review and meta-analysis

Outcome

MD/RR [95%CI]

I2

Quality of evidence

Reasons

The incidence of PND

0.87 [0.61, 1.24]

19%

HIGH

None

MMSE

0.00 [-0.66, 0.66]

0%

HIGH

None

Alertness

0.96 [0.42, 2.23]

0%

HIGH

None

Divided Attention

1.76 [0.12, 25.49]

52%

LOW

Inconsistency was “serious” a, imprecision was “serious”b

Working Memory

1.51 [0.53, 4.32]

0%

MODERATE

Imprecision was “serious”

To open eyes

-4.57 [-5.82, -3.33]

0%

MODERATE

Indirectness was “serious” c

To extubation

-5.30 [-6.61, -4.00]

0%

MODERATE

Indirectness was “serious”

Aldrete score

0.79 [0.24, 1.34]

71%

MODERATE

Inconsistency was “serious”

to react on demand

-3.56 [-6.35, -0.78]

0%

LOW

Indirectness was “serious”, imprecision was “serious”

To time and spatial orientation

-3.04 [-5.93, -0.14]

0%

LOW

Indirectness was “serious”, imprecision was “serious”

Sepsis

0.96 [0.27, 3.40]

37%

MODERATE

Inconsistency was “serious”

Respiratory infection/ inflammation

0.62 [0.30, 1.32]

0%

HIGH

None

Acute kidney injury

1.07 [0.53, 2.17]

5%

HIGH

None

Myocardial dysfunction/infarction

0.45 [0.13, 1.59]

0%

HIGH

None

Hypotension

0.89 [0.65, 1.22]

0%

HIGH

None

PONV

1.20 [0.67, 2.15]

0%

HIGH

None

Mortality

0.81 [0.08, 8.64]

52%

LOW

Inconsistency was “serious”, imprecision was “serious”

  1. CI Confidence intervals, PND Postoperative neurocognitive disorders, PONV postoperative nausea and vomiting, MD Mean difference, MMSE Mini-mental state examination scores RR Risk ratio
  2. aI2 > 30%, which indicated “inconsistency”, was graded as “serious”
  3. bfor outcomes have a wide confidence interval (gap > 3), we downgraded the level of certainty to “serious” for “imprecision”
  4. cthe results were reported as mean (95%CI), which indicated “indirectness” was classified as “serious”