Table 1 Demographic data and baseline hemodynamic characteristics. Data presented as mean ± standard deviation, median (quartiles), and frequency (%)
Ketofol-1:1 group (n = 37) | Ketofol-1:3 group (n = 35) | P-value | |
|---|---|---|---|
Age (years) | 41 ± 15 | 44 ± 16 | 0.416 |
Male sex | 28 (76%) | 23 (66%) | 0.120 |
Weight (kg) | 74 ± 13 | 73 ± 12 | 0.562 |
Body mass index (Kg.m− 2) | 25 (22, 27) | 26 (23, 29) | 0.542 |
ASA-PS I II III | 27 (73%) 9 (24%) 1 (3%) | 25 (71%) 10 (29%) 0 (0%) | 0.584 |
Comorbidities Diabetes Meletus Hypertension | 7 (19%) 5 (14%) | 8 (23%) 5 (14%) | 0.681 0.925 |
Baseline heart rate (bpm) | 87 ± 18 | 90 ± 14 | 0.899 |
Baseline mean arterial pressure (mmHg) | 95 ± 9 | 99 ± 10 | 0.058 |
Shock index | 0.66 ± 0.18 | 0.69 ± 0.13 | 0.500 |
Preoperative fluid (mL) | 300 (245, 350) | 300 (260, 480) | 0.337 |
Intubation time (seconds) | 40 (30, 40) | 40 (30, 40) | 0.834 |
Total ketofol volume (mL) | 11.5 ± 3.9 | 10.5 ± 4.0 | 0.288 |
Propofol dose (mg/kg) median (quartiles) mean ± standard deviation | 1.0 (0.5, 1.0) 0.8 ± 0.3 | 1.0 (0.8, 1.5) 1.1 ± 0.4 | 0.001 |
Ketamine dose (mg/kg) median (quartiles) mean ± standard deviation | 1.0 (0.5, 1.0) 0.8 ± 0.3 | 0.3 (0.3, 0.5) 0.4 ± 0.1 | < 0.001 |