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Table 1 Characteristics of patients breathing room air, intermittently receiving SO, or always receiving SO

From: Incidence of postoperative opioid-induced respiratory depression episodes in patients on room air or supplemental oxygen: a post-hoc analysis of the PRODIGY trial

Patient Characteristics

Always Room Air (n = 74)

Intermittent SO (n = 88)

Always SO (n = 40)

p-value

Age (yrs) (Mean ± SD)

49.4 ± 15.5

52.6 ± 12.9

56.0 ± 13.9

0.053

Body Mass Index (kg/m2) (Mean ± SD)

36.6 ± 12.3

36.2 ± 11.1

34.5 ± 12.6

0.440

Current Smoker

8.1% (6/74)

8.0% (7/88)

5.0% (2/40)

0.807

Oxygen Use at Home

0.0% (0/74)

1.1% (1/88)

2.5% (1/40)

1.0

ASA Physical Status

 ASA I

0.0% (0/74)

0.0% (0/88)

0.0% (0/40)

0.603

 ASA II

28.4% (21/74)

22.7% (20/88)

30.0% (12/40)

 ASA III

71.6% (53/74)

76.1% (67/88)

67.5% (27/40)

 ASA IV

0.0% (0/74)

1.1% (1/88)

2.5% (1/40)

PRODIGY Score

 Low (< 8)

53.4% (39/73)

43.2% (38/88)

27.5% (11/40)

0.123

 Intermediate (8–14)

27.4% (20/73)

30.7% (27/88)

40.0% (16/40)

 High (≥ 15)

19.2% (14/73)

26.1% (23/88)

32.5% (13/40)

SO Flow Rate (L/min) (Mean ± SD)

NA

2.1 ± 0.7

1.9 ± 0.7

0.538

Surgical Demographics

 High-Risk Surgerya

6.8% (5/74)

11.4% (10/88)

17.5% (7/40)

0.210

 Open Surgery

12.2% (9/74)

17.0% (15/88)

10.0% (4/40)

0.490

Opioid Demographics

 Opioid Naive

81.1% (60/74)

84.1% (74/88)

85.0% (34/40)

0.827

 Multiple Opioids or concurrent CNS/Sedating Medication

100.0% (74/74)

97.7% (86/88)

100.0% (40/40)

0.270

 Opioid Morphine Milligram Equivalents (post-surgery) (Median, IQR)

26.9 (7.6- 90.0)

27.1 (15.3- 60.2)

21.5 (12.4- 76.6)

0.798

Medical History

Cardiac Disorders

 Aortic Aneurysm

0.0% (0/74)

2.3% (2/88)

0.0% (0/40)

0.679

 Aortic Valve Disease

0.0% (0/74)

3.4% (3/88)

0.0% (0/40)

0.309

 Chronic Heart Failure

1.4% (1/73)

2.3% (2/88)

0.0% (0/40)

1.000

 Coronary Artery Disease

4.1% (3/73)

1.1% (1/88)

5.0% (2/40)

0.353

 Hypertension

43.2% (32/74)

56.8% (50/88)

47.5% (19/40)

0.214

 Mitral Valve Disease

1.4% (1/74)

1.1% (1/88)

0.0% (0/40)

1.000

 Myocardial Infarction

0.0% (0/73)

2.3% (2/88)

0.0% (0/40)

0.680

Sepsis

1.4% (1/74)

1.1% (1/88)

0.0% (0/40)

1.000

Metabolism and Nutrition Disorders

 Diabetes—Type I

1.4% (1/74)

3.4% (3/88)

0.0% (0/40)

0.537

 Diabetes—Type II

21.6% (16/74)

14.8% (13/88)

15.0% (6/40)

0.471

Kidney Failure

1.4% (1/74)

2.3% (2/88)

2.5% (1/40)

1.000

Respiratory Disorders

 Acute Bronchitis

0.0% (0/74)

1.1% (1/88)

5.0% (2/40)

0.149

 Asthma

23.0% (17/74)

21.6% (19/88)

7.5% (3/40)

0.105

 Chronic Bronchitis

0.0% (0/74)

1.1% (1/88)

0.0% (0/40)

1.000

 Chronic Obstructive Pulmonary

5.4% (4/74)

4.5% (4/88)

5.0% (2/40)

1.000

 Pneumonia

0.0% (0/74)

2.3% (2/88)

5.0% (2/40)

0.191

Sleep Disordered Breathingb

14.9% (11/74)

20.5% (18/88)

25.0% (10/40)

0.398

Vascular Disorders

 Cerebral Aneurysm

2.7% (2/74)

4.5% (4/88)

0.0% (0/40)

0.427

 Peripheral Vascular Disease

1.4% (1/74)

2.3% (2/88)

2.5% (1/40)

1.000

 Stroke

4.1% (3/73)

3.4% (3/88)

2.5% (1/40)

1.000

 Transient Ischemic Attack

2.7% (2/73)

1.1% (1/88)

2.5% (1/40)

0.678

  1. Abbreviations SO Supplemental oxygen, SD Standard deviation, ASA American Society of Anesthesiologists, PRODIGY PRediction of Opioid-induced respiratory Depression In patients monitored by capnography, CNS Central nervous system, IQR Interquartile range, NA Not applicable, L Liters, min, Minute, ESC/ESA European Society of Cardiology/European Society of Anaesthesiology
  2. aHigh-risk surgery was defined using the revised ESC/ESA guidelines on non-cardiac surgery
  3. bKnown or suspected sleep-disordered breathing included medical history of obstructive sleep apnea, the use of continuous positive airway pressure (CPAP), or confirmation of the Snoring, Tiredness, Observed apnea, blood Pressure (STOP) questions in the Snoring, Tiredness, Observed apnea, blood Pressure, Body mass index, Age, Neck circumference and Gender (STOP-BANG) questionnaire