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Fig. 6 | BMC Anesthesiology

Fig. 6

From: Dexamethasone inhibits IL-8 via glycolysis and mitochondria-related pathway to regulate inflammatory pain

Fig. 6

Dexa reduced IL-8 expression via glycolysis and mitochondrial pathway-related proteins, thus alleviating pain under inflammatory conditions. Intrathecal injection of Dexamethasone (Dexa) decreased the levels of GLUT3 (glycolysis-related protein) and Mfn2 (mitochondrial pathway-related protein), and further increased the PKM2 (glycolysis-related protein) expression. The antinociceptive effects of Dexa were counteracted by 2-DG (glycolysis inhibitor) or Oligo (mitochondrial pathway inhibitor) application. The upregulation of PKM2 induced by Dexa administration might be due to the stable Dexa-PKM2 binding, thus reducing the PKM2 activity and the quantity of the remaining PKM2.

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BMC Anesthesiology

ISSN: 1471-2253

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