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Fig. 1 | BMC Anesthesiology

Fig. 1

From: Dexamethasone inhibits IL-8 via glycolysis and mitochondria-related pathway to regulate inflammatory pain

Fig. 1

Intrathecal injection of Dexa alleviated FCA-induced inflammatory pain. (A–D) The effects of Dexa (20 µg/20 µL), 2-deoxyglucose (2-DG, 5 mg/20 µL, glycolysis inhibitor) or oligomycin complex (Oligo, 5 µg/20 µL, mitochondrial pathway inhibitor) following their single or combined administration on ipsilateral and contralateral paw withdrawal mechanical thresholds (PWMTs). Dexa significantly decreased the pain in the ipsilateral hind paw of the FCA-treated mice, which was reversed by 2-DG or Oligo administration (A, C), whereas the contralateral side remained unchanged (B, D). * P<0.05 versus control; # P<0.05 versus FCA group; and ▲ P<0.05 versus Dexa group in repeated measures ANOVA. Data are presented as mean ± SD (n = 6). FCA, Freund’s complete adjuvant

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BMC Anesthesiology

ISSN: 1471-2253

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