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Table 5 Effect size of anemia on LOS (Days) in prespecified and exploratory subgroups in Each Subgroup

From: The relationship between preoperative anemia and length of hospital stay among patients undergoing radical surgery for esophageal carcinoma: a single-centre retrospective study

Anemia LOS (days)

 

N

β 95%CI

interaction p-value

Age, (years) group

  

0.0570

<60

274

4.79 (1.33, 8.25)

 

>=60

373

0.61 (-2.03, 3.25)

 

Gender

  

0.4366

female

146

4.00 (0.02, 7.98)

 

male

501

2.02 (-0.44, 4.48)

 

Hypertension

  

0.0245

No

545

1.44 (-0.71, 3.58)

 

Yes

102

7.98 (1.33, 14.63)

 

Diabetes

  

0.8676

No

600

2.33 (0.30, 4.36)

 

Yes

47

3.00 (-9.53, 15.52)

 

Heart disease

  

0.4683

No

580

2.41 (0.19, 4.64)

 

Yes

67

3.30 (-3.15, 9.75)

 

Central nervous system

  

0.7084

No

633

2.43 (0.30, 4.57)

 

Yes

14

5.20 (-5.27, 15.67)

 

Lung disease

  

0.8431

No

497

2.27 (-0.07, 4.61)

 

Yes

150

2.76 (-1.94, 7.46)

 

Abnormal WBC

  

0.0111

No

579

1.41 (-0.74, 3.57)

 

Yes

68

9.99 (1.97, 18.01)

 

Abnormal Na+

  

0.2865

No

586

2.10 (-0.10, 4.30)

 

Yes

61

5.95 (-1.24, 13.15)

 

Abnormal K+

  

0.1797

No

587

1.98 (-0.26, 4.23)

 

Yes

60

6.79 (1.11, 12.48)

 

SCr, (umol/L) group

  

0.5045

<100

475

2.09 (-0.28, 4.46)

 

>=100

172

3.72 (-0.75, 8.18)

 

PT, (s) group

  

0.9905

<13

632

2.55 (0.40, 4.69)

 

>=13

15

2.46 (-3.32, 8.25)

 

APTT, (s) group

  

0.9160

<37

636

2.52 (0.38, 4.66)

 

>=37

11

3.39 (-3.97, 10.76)

 

Preoperative chemotherapy

  

0.9437

No

505

2.91 (0.37, 5.46)

 

Yes

142

3.11 (-1.77, 7.99)

 

ASA ≥ 3

  

0.7246

No

594

2.28 (0.09, 4.47)

 

Yes

53

3.61 (-4.15, 11.37)

 

Anesthesia method

  

0.7903

General + epidural

462

2.25 (-0.05, 4.54)

 

General

185

2.87 (-1.71, 7.45)

 

Operation form

  

0.5511

Minimally invasive

300

1.79 (-1.63, 5.22)

 

Open

347

3.07 (0.51, 5.62)

 

Operation time, (min) group

  

0.2774

<240

334

3.56 (0.89, 6.24)

 

>=240

313

1.25 (-2.01, 4.50)

 

Blood loss, (ml) group

  

0.7595

<200

287

2.84 (-0.42, 6.10)

 

>=200

360

2.18 (-0.57, 4.93) 0

 

Fluid infusion, (ml) group

  

0.6503

<2000

39

4.52 (-2.00, 11.05)

 

>=2000, < 3000

396

3.02 (0.17, 5.87)

 

>=3000

212

1.20 (-2.25, 4.64)

 

Preoperative RBC infusion

  

0.5828

No

520

2.30 (-0.11, 4.71)

 

Yes

127

0.86 (-3.72, 5.43)

 

Postoperative admission to ICU

  

0.0101

No

605

1.49 (-0.44, 3.41)

 

Yes

42

12.07 (-2.92, 27.05)

 

Respiratory failure

  

0.5127

No

623

2.34 (0.20, 4.49)

 

Yes

24

6.02 (-3.92, 15.97)

 

Lung infection

  

0.1027

No

435

1.11 (-0.83, 3.06)

 

Yes

212

4.77 (-0.12, 9.67)

 

Anastomotic fistula

  

0.8244

No

605

2.69 (1.09, 4.28)

 

Yes

42

3.54 (-12.96, 20.03)

 

Cardiovascular complication

  

0.8043

No

614

2.29 (0.19, 4.38)

 

Yes

33

5.76 (-7.50, 19.02)

 
  1. Abbreviations: LOS, length of stay; WBC,white blood cells; Na+, Serum sodium ion; K+, Serum potassium ion; SCr, Serum creatinine; PT, prothrombin time; APTT, activated partial thromboplastin time; ASA, American Society of Anesthesiologist; RBC, red blood cell; ICU, Intensive care unti
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