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Table 2 Intraoperative and postoperative variables

From: Dexmedetomidine as an anesthetic adjunct is associated with reduced complications and cardiac intensive care unit length of stay after heart valve surgery

 

Adverse outcomes(n = 283)

Control(n = 573)

P value

Intraoperative variables

 Type of cardiac surgery (n, %)

  

0.442

  AVR

94 (33.2)

205 (35.8)

 

  MVR

83 (29.3)

164 (28.6)

 

  DVR

45 (15.9)

66 (11.5)

 

  CABG + valvular surgery

13 (4.6)

28 (4.9)

 

  Valvular + other aortic surgery

48 (17.0)

110 (19.2)

 

  ASA Classification > 3 (n,%)

249 (88.0)

477 (83.2)

0.069

  Operation time( minutes)

295 (250–360)

270 (230–325)

 < 0.001

  CPB( minutes)

150 (119–188)

134 (107–163)

 < 0.001

  ACC(minutes)

110 (85–144)

98 (79–126)

 < 0.001

  Intraoperative bleeding(ml)

800 (600–1200)

800 (600–1100)

0.005

Intraoperative RBC

 transfusion(ml)

450 (0–1050)

350 (0–904)

0.135

 Urine volume(ml)

800 (500–1300)

800 (500–1400)

0.544

Maximum HR(bpm)

 Preoperative

65 (55–80)

68 (59–80)

0.544

 End of surgery

93 (85–101)

90 (80–98)

 < 0.001

Maximum MAP(mmHg)

 Preoperative

80 (73–86)

80 (73–87)

0.175

 End of surgery

73 (67–79)

74 (68–80)

0.058

Intraoperative drugs

 Dextrmetomidine(n,%)

212(74.9)

482(84.1)

0.001

 Milrinone(mg)

2.7 (2.1–3.8)

2.6 (2.1–3.2)

0.023

 Norepinephrine(mg)

1.4 (1.1–1.9)

1.3 (1.1–1.7)

0.206

 Dopamine(mg)

45.0 (35.1–62.7)

42.2 (34.0–53.6)

0.007

Postoperative variables

 Blood gas analysis within 24 h

  Sp02(%)

99 (98–100)

99 (98–100)

0.956

  PH

7.40 (7.38–7.43)

7.40 (7.38–7.42)

0.048

  PaCO2(mmHg)

38.6 (35.0–41.7)

39.6 (37.3–42.0)

0.002

  PaO2(mmHg)

108.1(89.6–142.9)

107 (90.6–126.85)

0.641

  Hb(mmol/L)

10.2 (9.2–11.0)

10.4 (9.6–11.3)

0.001

  K + (mmol/L)

4.4 (4.2–4.7)

4.5 (4.2–4.7)

0.377

  Lac(mmol/L)

1.7 (1.3–2.5)

1.6 (1.2–2.3)

0.212

  Mechanical ventilation time (hours)

13 (7–20)

7 (5–14)

 < 0.001

  CICU time (days)

4 (3–6)

3 (3–4)

 < 0.001

  Cardiac arrest(n, %)

3 (1.1)

0 (0)

0.014

  Atrial fibrillation (n, %)

118 (41.7)

0 (0)

 < 0.001

  Myocardial injury/infarction(n, %)

121 (42.8)

0 (0)

 < 0.001

  Heart failure(n, %)

126 (44.5)

0 (0)

 < 0.001

  1. AVR Aortic valve replacement/repair, MVR Mitral valve replacement/repair, DVR Double valve replacement/repair, CABG Coronary artery bypass grafting, ASA American society of Aneshesiologists, CPB Cardiopulmonary Bypass, ACC Aortic Cross Clamp, RBC Red Blood Cell, HR Heart Rate, MAP Mean Artery Pressure, SpO2 Peripheral capillary oxygen saturation, PH Potential of Hydrogen, PaCO2 Partial pressure of Carbon dioxide, PaO2 Partial pressure of Oxygen, Hb Hemoglobin, Lac Lactobacillus acidophilus, CICU Cardiac intensive care unit