Variables | Subgroup | Crude HR (95%CI) | p for interaction | Adjusted HR (95%CI) | p for interaction |
---|---|---|---|---|---|
Age | < 65 | 1.750 (1.585–1.933) | 0.792 | 1.505 (1.342–1.688) | 0.982 |
≥ 65 | 1.711 (1.567–1.869) | 1.615 (1.474–1.770) | |||
Sex | Female | 2.105 (1.908–2.321) | < 0.001 | 1.696 (1.514-1.900) | 0.004 |
Male | 1.648 (1.519–1.788) | 1.482 (1.352–1.624) | |||
Body mass index | < 21.5 | 1.671 (1.527–1.829) | 0.115 | 1.479 (1.333–1.642) | 0.302 |
≥ 21.5 | 1.853 (1.702–2.017) | 1.580 (1.435–1.740) | |||
CCI | < 2 | 1.988 (1.780–2.220) | < 0.001 | 1.838 (1.617–2.090) | < 0.001 |
≥ 2 | 1.489 (1.372–1.617) | 1.478 (1.360–1.607) | |||
APACHE II score | < 25 | 1.905 (1.771–2.049) | < 0.001 | 1.675 (1.538–1.825) | < 0.001 |
≥ 25 | 1.312 (1.156–1.489) | 1.202 (1.052–1.374) | |||
Presence of shock | No | 1.868 (1.718–2.031) | 0.083 | 1.568 (1.424–1.727) | 0.421 |
Yes | 1.653 (1.498–1.825) | 1.523 (1.366–1.699) | |||
Surgical divisions | CVS | 2.623 (2.213–3.109) | 0.927 | 2.391 (1.990–2.873) | 0.064 |
Neurosurgery | 2.447 (1.987–3.015) | 1.826 (1.435–2.325) | |||
Abdomen surgery | 1.400 (1.127–1.739) | 1.287 (1.027–1.611) | |||
Hemodialysis | No | 2.189 (2.018–2.373) | < 0.001 | 1.832 (1.672–2.008) | < 0.001 |
Yes | 1.214 (1.014–1.454) | 1.226 (1.020–1.474) | |||
Fluid balance, day 1–3 | Negative | 2.068 (1.841–2.321) | 0.010 | 1.707 (1.495–1.949) | 0.108 |
Positive | 1.701 (1.579–1.833) | 1.511 (1.388–1.644) | |||
Positive microbiological culture | No | 2.045 (1.832–2.284) | < 0.001 | 1.679 (1.478–1.906) | < 0.001 |
Yes | 1.427 (1.308–1.556) | 1.281 (1.164–1.410) | |||
White blood cell count (/µl) | < 12,000 | 1.875 (1.734–2.027) | 0.096 | 1.621 (1.480–1.775) | 0.113 |
≥ 12,000 | 1.673 (1.511–1.853) | 1.443 (1.283–1.622) | |||
Haemoglobin (g/dL) | < 10 | 1.322 (1.207–1.448) | < 0.001 | 1.201 (1.088–1.327) | < 0.001 |
≥ 10 | 2.387 (2.118–2.690) | 1.926 (1.678–2.211) | |||
Platelet (103/µL) | < 150 | 1.594 (1.447–1.756) | 0.003 | 1.483 (1.335–1.647) | 0.094 |
≥ 150 | 1.943 (1.781–2.119) | 1.617 (1.461–1.789) | |||
Creatinine (mg/dL) | < 1.5 | 3.656 (3.176–4.208) | < 0.001 | 3.236 (2.730–3.835) | < 0.001 |
≥ 1.5 | 1.380 (1.228–1.550) | 1.353 (1.199–1.527) |