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Table 3 Effect modification of variables on the association between week-one ratio of BUN/Albumin and risk of post-hospital mortality in critically ill surgical patients

From: Association between early blood urea nitrogen-to-albumin ratio and one-year post-hospital mortality in critically ill surgical patients: a propensity score-matched study

Variables

Subgroup

Crude

HR (95%CI)

p for interaction

Adjusted

HR (95%CI)

p for interaction

Age

< 65

1.750 (1.585–1.933)

0.792

1.505 (1.342–1.688)

0.982

 

≥ 65

1.711 (1.567–1.869)

 

1.615 (1.474–1.770)

 

Sex

Female

2.105 (1.908–2.321)

< 0.001

1.696 (1.514-1.900)

0.004

 

Male

1.648 (1.519–1.788)

 

1.482 (1.352–1.624)

 

Body mass index

< 21.5

1.671 (1.527–1.829)

0.115

1.479 (1.333–1.642)

0.302

 

≥ 21.5

1.853 (1.702–2.017)

 

1.580 (1.435–1.740)

 

CCI

< 2

1.988 (1.780–2.220)

< 0.001

1.838 (1.617–2.090)

< 0.001

 

≥ 2

1.489 (1.372–1.617)

 

1.478 (1.360–1.607)

 

APACHE II score

< 25

1.905 (1.771–2.049)

< 0.001

1.675 (1.538–1.825)

< 0.001

 

≥ 25

1.312 (1.156–1.489)

 

1.202 (1.052–1.374)

 

Presence of shock

No

1.868 (1.718–2.031)

0.083

1.568 (1.424–1.727)

0.421

 

Yes

1.653 (1.498–1.825)

 

1.523 (1.366–1.699)

 

Surgical divisions

CVS

2.623 (2.213–3.109)

0.927

2.391 (1.990–2.873)

0.064

 

Neurosurgery

2.447 (1.987–3.015)

 

1.826 (1.435–2.325)

 
 

Abdomen surgery

1.400 (1.127–1.739)

 

1.287 (1.027–1.611)

 

Hemodialysis

No

2.189 (2.018–2.373)

< 0.001

1.832 (1.672–2.008)

< 0.001

 

Yes

1.214 (1.014–1.454)

 

1.226 (1.020–1.474)

 

Fluid balance, day 1–3

Negative

2.068 (1.841–2.321)

0.010

1.707 (1.495–1.949)

0.108

 

Positive

1.701 (1.579–1.833)

 

1.511 (1.388–1.644)

 

Positive microbiological culture

No

2.045 (1.832–2.284)

< 0.001

1.679 (1.478–1.906)

< 0.001

Yes

1.427 (1.308–1.556)

 

1.281 (1.164–1.410)

 

White blood cell count (/µl)

< 12,000

1.875 (1.734–2.027)

0.096

1.621 (1.480–1.775)

0.113

 

≥ 12,000

1.673 (1.511–1.853)

 

1.443 (1.283–1.622)

 

Haemoglobin (g/dL)

< 10

1.322 (1.207–1.448)

< 0.001

1.201 (1.088–1.327)

< 0.001

 

≥ 10

2.387 (2.118–2.690)

 

1.926 (1.678–2.211)

 

Platelet (103/µL)

< 150

1.594 (1.447–1.756)

0.003

1.483 (1.335–1.647)

0.094

 

≥ 150

1.943 (1.781–2.119)

 

1.617 (1.461–1.789)

 

Creatinine (mg/dL)

< 1.5

3.656 (3.176–4.208)

< 0.001

3.236 (2.730–3.835)

< 0.001

 

≥ 1.5

1.380 (1.228–1.550)

 

1.353 (1.199–1.527)

 
  1. Abbreviations: BUN, blood urea nitrogen; HR, hazard ratio; CI, confidence interval; CCI, Charlson comorbidity index; APACHE IV, acute physiology and chronic health evaluation IV; CVS, cardiovascular surgery