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Table 1 Baseline characteristic of included studies

From: The effect of intravenous lidocaine on postoperative cognitive dysfunction: a systematic review and meta-analysis

 

Mitchell et al. 1999

Wang et al. 2002

Mathew et al. 2009

Mitchell et al. 2009

Peng et al. 2016

Chen et al. 2015

Klinger et al. 2019

Hashemi et al. 2013

Zhu et al. 2015

Wang et al. 2004

Lid

Con

Lid

Co

Lid

Co

Lid

Co

Lid

Con

Lid

Con

Lid

Con

Lid

Con

Lid

Con

Lid

Con

Age*

56.9 ± 8.9

54.4 ± 9.7

57.8 ± 9.7

59.3 ± 9.4

61.7 ± 11.9

61.4 ± 13.9

61.5 ± 9.6

58.1 ± 11.4

45 ± 9

44 ± 10

71.3 ± 2.0

71.8 ± 1.9

67 ± 9.1

67 ± 9.5

66 ± 1

67 ± 2

71.9 ± 3.8

73.1 ± 4.2

58 ± 10

59 ± 9

Male (%)

17 (60.7)

14 (51.9)

42 (97.7)

44 (97.8)

83 (72.8)

85 (67)

60 (74.1)

63 (81.8)

20 (50)

19 (47.5)

25 (62.5)

13 (57.7)

151 (71.6)

160 (76.6)

27 (77.1)

28 (80)

13 (43.3)

13 (43.3)

42 (97.7)

44 (97.8)

Sample size

28

27

43

45

133

144

81

77

40

40

40

40

211

209

35

35

30

30

43

45

Education*

9.78 ± 3.0

9.81 ± 2.4

9.6 ± 3.5

10.1 ± 3.9

13.3 ± 3.4

12.7 ± 3.3

NA

NA

12.25 ± 3.43

12.75 ± 3.19

NA

NA

14.3 ± 2.99

15.3 ± 2.99

NA

NA

5.9 ± 2.3

6.2 ± 2.4

10 ± 3

10 ± 4

MMSE score

NP test

NP test

NP test, occurrence

NP test, occurrence

Cognitive index, Occurrence

Cognitive index, Occurrence

Occurrence

Occurrence

28.65 ± 0.77

29 ± 1.54

28.77 ± 1.85

28.19 ± 0.98

Cognitive index, Occurrence

Cognitive index, Occurrence

25.9 ± 4

25.7 ± 3.9

27.3 ± 1.7, NP test, occurrence

26.9 ± 1.4, NP test, occurrence

NP test, occurrence

NP test, occurrence

surgery

CABG with CPB, valve surgery

CABG with CPB

CABG with CPB

CABG with CPB, valve surgery

Supratentorial craniotomy for tumor surgery

Spine surgery

CABG, CABG with valve, valve

Urologic and orthopedic

Gastrointestinal tumor surgery

CABG with CPB

Follow-up

10d, 10wk, 6mo

9d

6wk, 1yr

 

24 h, 1wk, 1mo, 3mo, 6mo

3d

6mo, 1yr

leaving PACU, 6 h, 24 h

2d

9d

Jadad score

3

4

5

4

5

4

5

5

4

3

  1. *Data are reported as mean ± SD;Lid indicates Lidocaine; Con indicates Control