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Table 2 Univariate analysis for 30-day in-hospital mortality among patients with ARF due to COVID-19 pneumonia who failed in HFNC and were subsequently intubated

From: Delayed intubation associated with in-hospital mortality in patients with COVID-19 respiratory failure who fail heated and humified high flow nasal canula

  

MORTALITY (%)

OR (95% CI)

P VALUES

SEX

Male

64.7

1.44 (1.15, 1.80)

0.0013

Female

56

  

AGE (YEARS)

 ≥ 50

66.5

4.42 (3.19, 6.10)

 < .0001

18—49

31

  

COPD

Yes

60.7

0.97 (0.77, 1.23)

0.8

No

61.4

  

HF

Yes

64.3

1.19 (0.90, 1.56)

0.22

No

60.3

  

DM

Yes

66.4

1.37 (1.06, 1.76)

0.014

No

59.1

  

HTN

Yes

62.6

1.23 (0.96, 1.56)

0.095

No

57.7

  

CKD

Yes

71.8

1.85 (1.41, 2.44)

 < .0001

No

57.9

  

TROPONIN (NG/L)

 > 28

70.9

1.7 (1.26, 2.29)

0.0004

 ≤ 28

58.9

  

CREATININE (MG/DL)

 > 1.5

75.1

2.2 (1.61, 2.99)

 < .0001

 ≤ 1.5

57.9

  

CRP (MG/L)

 > 100

59

0.88 (0.69, 1.11)

0.28

 ≤ 100

62.1

  

LYMPHOCYTES (ΜL)

 ≤ 1

62.2

0.82 (0.63, 1.07)

0.14

 > 1

57.4

  

NT-PROBN (PG/ML)

 > 88

63.6

1.16 (0.91, 1.48)

0.23

 ≤ 88

60.1

  

HFNC DURATION

 > 24 h

67.2

2.16 (1.71, 2.74)

 < .0001

 ≤ 24 h

48.6

  
  1. Table 2. Univariate analysis shows that among patients with COVID-19 ARF who failed HFNC and were intubated; male sex, older age, prior diagnosis of diabetes mellitus (DM), a history of chronic kidney disease (CKD), elevated high sensitivity troponin, elevated serum creatinine and prolonged duration of HFNC prior to intubation were all associated with increased in-hospital mortality