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Table 3 Diagnostic Performance of PPV, SVV and changes in ANIm

From: Ability of the Analgesia Nociception Index variations to identify a response to a volume expansion of 250 mL of crystalloids in the operating room (REVANI): a prospective observational study

 

AUC

Best threshold

Specificity

Sensitivity

PV + 

PV-

LR + 

LR-

Youden

P value

Diagnosis performance for detecting fluid responsiveness defined by an increase in SV more than 10%

 DeltaANIm

0,479

[0,340 – 0,617]

11%

0,568

[0,405 – 0,730]

0,500

[0,312 – 0,656]

0,500

[0,367 – 0,625]

0,568

[0,455 – 0,677]

1,156

[0,634 – 1,854]

0,881

[0,535 – 1,374]

0,068

ref

 SVV

0,464

[0,326 – 0,603]

7%

0,054

[0,000 – 0,135]

1,000

[0, 0, 1]

0,478

[0,464 – 0,500]

1,000

[0, 0, 1]

1,057

[0,979 – 1,142]

0,000

[0–6, 86]

0,054

0,887

 PPV

0,525

[0,385 – 0,664]

19%

0,865

[0,757 – 0,973]

0,250

[0,094 – 0,406]

0,625

[0,357 – 0,867]

0,571

[0,517 – 0,632]

1,850

[0,666 – 8,252]

0,867

[0,657 – 1,076]

0,115

0,634

Diagnosis performance for detecting fluid responsiveness defined by an increase in CO more or equal than 10%

 DeltaANIm

0,614

[0,464 – 0,763]

12%

0,490

[0,347 -,0633]

0,750

[0,550 – 0,900]

0,375

[0,286 – 0,471]

0,829

[0,706- 0,935]

1,470

[0,975 – 2,129]

0,510

[0,152 – 1,019]

0,828

ref

 SVV

0,546

[0,399 – 0,694]

14%

0,633

[0,490 – 0,755]

0,550

[0,350 – 0,750]

0,379

[0,250 – 0,522]

0,775

[0,684 – 0,872]

1,497

[0,804 – 2,538]

0,711

[0,352 – 1,122]

0,183

0543

 PPV

0,555

[0,406 – 0,704]

12%

0,633

[0,510 – 0,755]

0,600

[0,400 – 0,800]

0,400

[0,276 – 0,533]

0,795

[0,702 – 0,895]

1,633

[0,933 – 2,768]

0,632

[0,290 – 1,036]

0,795

0,575

  1. ANI Analgesia Nociceptive Index, AUC Area Under Curve, CI Confidence Interval, ΔANIm Changes in ANI following volume expansion, LR- Negative Likelihood Ratio, LR +  Positive Likelihood Ratio, PV +  Positive Predictive Value, PV- Negative Predictive Value, PPV Pulse Pressure Variations, SV Stroke Volume, SVV Stroke Volume Variations