Table 3 Ketamine and placebo interventions for the IMPAKT ERAS trial

Intravenous Ketamine Intervention

 Intraoperative:

  0.5 mg/kg bolus at anesthetic induction followed by intraoperative infusion of 5 mcg/kg/min until fascial closure, up to a maximum of 100 kg

 Postoperative:

  Infusion of 2.5 mcg/kg/min begun in PACU and continued for 48 h postoperatively or until discontinued, up to a maximum of 100 kg

Placebo Intervention

 Intraoperative:

  Placebo normal saline bolus and infusion of an equivalent volume mirroring the ketamine intervention

 Postoperative:

  Placebo normal saline infusion of an equivalent volume mirroring the ketamine intervention, continued for 48 h postoperatively or until discontinued