Skip to main content
Fig. 2 | BMC Anesthesiology

Fig. 2

From: Activation of astrocytes in the basal forebrain in mice facilitates isoflurane-induced loss of consciousness and prolongs recovery

Fig. 2

Clozapine N-oxide (CNO) specifically activates astrocytes that express hM3Dq. (A-D) Representative images of c-Fos expression (green) in the group with CNO administration, in which astrocytes are activated (scale bar, 100 μm). White arrows indicate the co-labeled of c-Fos and mCherry. (E) Representative images of c-Fos expression (green) in the group with saline administration, in which astrocytes are not activated (scale bar, 100 μm). White arrows indicate the co-labeled of c-Fos and mCherry. (F) CNO administration to mice expressing hM3Dq in basal forebrain astrocytes results in a significantly higher c-Fos expression than those administrated with saline. The asterisk indicates a significant difference (***P < 0.001; 9 slices from 3 mice)

Back to article page

BMC Anesthesiology

ISSN: 1471-2253

Contact us