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Table 2 Characteristics of analgesia, labor and newborn outcome

From: Low-dose intranasal dexmedetomidine premedication improves epidural labor analgesia onset and reduces procedural pain on epidural puncture: a prospective randomized double-blind clinical study

 

CON (n = 30)

IND (n = 30)

Z/t/x2

P value

Onset of analgesia (min)

10.0 (8.5–11.5)

6.0 (4.9–7.1)

8.532

0.003

VAS during epidural puncture

3.5 (3.3–4.5)

2.0 (1.8–2.5)

-4.892

0.000

Consumption of ropivacaine (mg)

54.8 ± 24.4

40.9 ± 25.4

2.153

0.036

Consumption of sufentanil (μg)

27.4 ± 12.2

20.5 ± 12.7

2.153

0.036

Number of total PCEA boluses (n)

2.0 (1.3–2.6)

1.0 (0.6–1.3)

-2.540

0.011

Maternal satisfaction (n, %)

9.0 (8.2–8.9)

9.0 (9.1–9.5)

-3.261

0.001

Failed to reach onset of analgesia (n, %)

6 (20.0)

2 (6.7)

1.298

0.255

Duration of first stage (min)

420.0 (397.1–577.8)

360.0 (365.3–541.9)

-0.632

0.528

Duration of second stage (min)

37.0 (32.7–55.4)

39.0 (34.0–61.8)

-0.240

0.811

Mode of delivery (n, %)

  

0.000

1.000

 Vaginal

29 (96.7)

28 (93.3)

  

 Cesarean delivery

1 (3.3)

2 (6.7)

  

Postpartum bleeding (ml)

150 (139.9–445.5)

150 (157.3–207.4)

-0.456

0.649

Neonatal Apgar score

 1 min

9.0 (8.8–9.1)

9.0 (8.8–9.1)

-0.023

0.982

 5 min

10.0 (9.8–10.0)

10.0 (9.8–10.0)

-0.463

0.643

Umbilical artery PH

7.3 ± 0.1

7.3 ± 0.0

-0.533

0.596

Umbilical artery PaO2 (mmHg)

32.6 ± 4.3

33.7 ± 4.1

-0.994

0.324

Umbilical artery Lac (mmol/L)

2.7 ± 0.6

2.6 ± 0.7

0.381

0.705

  1. Values are presented as mean ± SD, n (%) or median (95% CI) depending on the distribution of the sample. P < 0.05 is set to be significant. CON, the conventional PIEB group; IND, the PIEB with intranasal dexmedetomidine group; PIEB, programmed intermittent epidural bolus. VAS, Visual analog scale; PCEA, Patient-controlled epidural analgesia; PH, Pondus Hydrogenii; Lac, Lactic acid level; PaO2, Partial arterial oxygen pressure