Effect of driving pressure on early postoperative lung gas distribution in supratentorial craniotomy: a randomized controlled trial

Table 2 Patient ventilatory mechanics and gas analysis

Characteristics	control group (n = 26)	titration group	p
Characteristics	control group (n = 26)	(n = 25)	Time	Group	Interaction
Compliance (ml·cmH₂O^− 1)			0.082	0.045	< 0.001
immediately after intubation	46 (42,49)	45 (42,48)
1 h after intubation	41 (37,46)	48 (42,54) *
end of surgery	41 (37,44)	46 (42,51) *
Ppeak (cmH₂O)			< 0.001	0.065	0.262
immediately after intubation	14 (13,16)	14 (12,16)
1 h after intubation	18 (17,19)	15 (14,18)
end of surgery	18 (17,19)	16 (15,19)
Pplat (cmH₂O)			< 0.001	0.064	0.003
immediately after intubation	14 (13,15)	13 (12,15)
1 h after intubation	17 (14,18)	15 (13,17)
end of surgery	17 (16,18)	15 (14,17)
PaCO₂			< 0.001	0.648	0.042
preinduction	38 (36,41)	37 (35,39)
1 h after intubation	36 (35,39)	35 (33,37)
immediately after extubation	47 (42,50)	46 (41,49)
1 h after extubation	39.6 (5.4)	43 (38,47)
pH			< 0.001	0.612	0.971
preinduction	7.42 (7.41,7.44)	7.43 (7.40,7.46)
1 h after intubation	7.43 (7.41,7.44)	7.42 (7.40,7.46)
immediately after extubation	7.34 (7.32,7.38)	7.35 (7.33,7.40)
1 h after extubation	7.37 (7.35,7.40)	7.37 (7.36,7.40)
PaO₂/FiO₂			0.001	0.011	0.117
preinduction	386 (341,473)	414 (384,475)
1 h after intubation	321 (274,382)	390 (330,428) *
immediately after extubation	323 (278,377)	373 (338,409) *
1 h after extubation	309 (241,361)	382 (296,494)

Data are presented as the Median (IQR).Ppeak, airway peak pressure; Pplat, airway plateau pressure. PaCO₂, partial pressure of carbon dioxide in arterial blood; PaO₂/FiO₂, the ratio of arterial partial pressure of oxygen to inspiratory oxygen fraction. *, p < 0.05 compared to the control group

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