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Table 4 Cox regression analysis for 90-day all-cause mortality in cardiogenic shock patients after matching

From: Association between short-term systemic use of glucocorticoids and prognosis of cardiogenic shock: a retrospective analysis

 

Univariable regression

Multivariable regression

HR (95% CI)

P value

HR (95% CI)

P value

Age, per 1 year

1.03 (1.02–1.04)

< 0.001

1.03 (1.02–1.04)

< 0.001

Male

1.16 (0.93–1.45)

0.178

–

 

BMI, per 1 kg/m2

1.00 (0.98–1.01)

0.736

–

 

Charlson comorbidity index, per 1 score

1.13 (1.09–1.18)

< 0.001

1.08 (1.03–1.14)

0.003

SOFA, per 1 score

1.03 (0.99–1.07)

0.167

–

 

OASIS, per 1 score

1.05 (1.04–1.06)

< 0.001

1.00 (0.98–1.02)

0.679

APS III, per 1 score

1.02 (1.01–1.02)

< 0.001

1.01 (1.00–1.02)

0.011

LODS, per 1 score

1.13 (1.09–1.16)

< 0.001

1.02 (0.96–1.09)

0.443

SBP, per 1 mmHg

0.99 (0.99–1.00)

0.023

0.99 (0.99–1.00)

0.055

DBP, per 1 mmHg

0.99 (0.99–1.00)

0.099

–

 

Heart rate, per 1 bpm

1.01 (1.00–1.01)

0.013

1.01 (1.00–1.01)

0.003

Hypertension

0.77 (0.60–1.00)

0.051

–

 

Diabetes

1.08 (0.86–1.36)

0.498

–

 

Dyslipidemia

0.94 (0.76–1.18)

0.602

–

 

CKD

1.78 (1.43–2.22)

< 0.001

1.30 (0.97–1.74)

0.076

Rheumatic disease

0.74 (0.42–1.32)

0.313

–

 

Chronic pulmonary disease

0.91 (0.72–1.14)

0.398

–

 

ADHF

0.66 (0.53–0.82)

< 0.001

0.60 (0.47–0.76)

< 0.001

MI

1.23 (0.99–1.53)

0.065

–

 

Cardiac arrest

1.60 (1.23–2.10)

0.001

1.58 (1.17–2.12)

0.003

Septic shock

1.92 (1.53–2.42)

< 0.001

1.32 (1.02–1.70)

0.037

Lactate, per 1 mmol/L

1.12 (1.08–1.16)

< 0.001

1.08 (1.03–1.13)

0.001

WBC, per 1 × 109/L

1.01 (0.99–1.02)

0.455

–

 

Platelet, per 1 × 109/L

1.00 (1.00–1.00)

0.170

–

 

RBC, per 1 × 1012/L

0.88 (0.77–1.01)

0.071

–

 

Hemoglobin, per 1 g/L

0.97 (0.92–1.02)

0.196

–

 

AST, per 1 IU/L

1.00 (1.00–1.00)

< 0.001

1.00 (1.00–1.00)

0.128

ALT, per 1 IU/L

1.00 (1.00–1.00)

0.003

1.00 (1.00–1.00)

0.382

Albumin, per 1 g/dL

0.83 (0.69–0.99)

0.041

0.92 (0.76–1.12)

0.420

BUN, per 1 mg/dL

1.01 (1.01–1.01)

< 0.001

1.01 (1.00–1.01)

0.073

Creatinine, per 1 mg/dL

1.11 (1.05–1.18)

< 0.001

0.92 (0.83–1.02)

0.133

Bicarbonate, per 1 mmol/L

0.96 (0.94–0.99)

0.002

0.99 (0.97–1.02)

0.666

pH, per 0.01

0.95 (0.73–1.22)

0.663

–

 

BE, per 1 mmol/L

1.00 (0.99–1.00)

0.519

–

 

Glucose, per 1 mg/dL

1.00 (1.00–1.00)

0.182

–

 

Sodium, per 1 mmol/L

1.00 (0.98–1.03)

0.660

–

 

Potassium, per 1 mmol/L

1.04 (0.93–1.18)

0.469

–

 

Chloride, per 1 mmol/L

0.99 (0.98–1.01)

0.385

–

 

Calcium, per 1 mg/dL

1.02 (0.91–1.14)

0.707

–

 

Magnesium, per 1 mg/dL

1.21 (0.99–1.49)

0.061

–

 

INR, per 0.1

1.08 (0.99–1.17)

0.083

–

 

PTT, per 1 s

1.00 (1.00–1.00)

0.683

–

 

Antiplatelet

0.60 (0.47–0.77)

< 0.001

0.77 (0.58–1.01)

0.059

Statins

0.83 (0.66–1.05)

0.117

–

 

Inotropes

1.14 (0.91–1.43)

0.267

–

 

Vasopressors

1.51 (1.10–2.08)

0.011

0.96 (0.67–1.38)

0.839

MCS

0.96 (0.68–1.36)

0.829

–

 

CRRT

1.73 (1.35–2.20)

< 0.001

1.29 (0.97–1.73)

0.083

Revascularization

0.59 (0.44–0.78)

< 0.001

0.81 (0.59–1.1)

0.180

Mechanical ventilation

1.09 (0.85–1.41)

0.503

–

 

Glucocorticoids

1.34 (1.07–1.67)

0.010

1.42 (1.13–1.79)

0.003

  1. BMI Body mass index, SOFA Sequential organ failure assessment, OASIS Oxford acute severity of illness score, APS III Acute physiology score III, LODS Logistic organ dysfunction system, SBP Systolic blood pressure, DBP Diastolic blood pressure, CKD Chronic kidney disease, ADHF Acute decompensated heart failure, MI Myocardial infarction, WBC White blood cell, RBC Red blood cell, AST Aspartate aminotransferase, ALT Alanine aminotransferase, BUN Blood urea nitrogen, BE Base excess, INR International normalized ratio, PTT Partial thromboplastin time, MCS Mechanical circulatory support, CRRT Continuous renal replacement therapy, HR Hazard ratio, CI Confidence interval