| Univariable regression | Multivariable regression | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age, per 1 year | 1.03 (1.02–1.04) | < 0.001 | 1.03 (1.02–1.04) | < 0.001 |
Male | 1.16 (0.93–1.45) | 0.178 | – |  |
BMI, per 1 kg/m2 | 1.00 (0.98–1.01) | 0.736 | – |  |
Charlson comorbidity index, per 1 score | 1.13 (1.09–1.18) | < 0.001 | 1.08 (1.03–1.14) | 0.003 |
SOFA, per 1 score | 1.03 (0.99–1.07) | 0.167 | – |  |
OASIS, per 1 score | 1.05 (1.04–1.06) | < 0.001 | 1.00 (0.98–1.02) | 0.679 |
APS III, per 1 score | 1.02 (1.01–1.02) | < 0.001 | 1.01 (1.00–1.02) | 0.011 |
LODS, per 1 score | 1.13 (1.09–1.16) | < 0.001 | 1.02 (0.96–1.09) | 0.443 |
SBP, per 1 mmHg | 0.99 (0.99–1.00) | 0.023 | 0.99 (0.99–1.00) | 0.055 |
DBP, per 1 mmHg | 0.99 (0.99–1.00) | 0.099 | – |  |
Heart rate, per 1 bpm | 1.01 (1.00–1.01) | 0.013 | 1.01 (1.00–1.01) | 0.003 |
Hypertension | 0.77 (0.60–1.00) | 0.051 | – |  |
Diabetes | 1.08 (0.86–1.36) | 0.498 | – |  |
Dyslipidemia | 0.94 (0.76–1.18) | 0.602 | – |  |
CKD | 1.78 (1.43–2.22) | < 0.001 | 1.30 (0.97–1.74) | 0.076 |
Rheumatic disease | 0.74 (0.42–1.32) | 0.313 | – |  |
Chronic pulmonary disease | 0.91 (0.72–1.14) | 0.398 | – |  |
ADHF | 0.66 (0.53–0.82) | < 0.001 | 0.60 (0.47–0.76) | < 0.001 |
MI | 1.23 (0.99–1.53) | 0.065 | – |  |
Cardiac arrest | 1.60 (1.23–2.10) | 0.001 | 1.58 (1.17–2.12) | 0.003 |
Septic shock | 1.92 (1.53–2.42) | < 0.001 | 1.32 (1.02–1.70) | 0.037 |
Lactate, per 1 mmol/L | 1.12 (1.08–1.16) | < 0.001 | 1.08 (1.03–1.13) | 0.001 |
WBC, per 1 × 109/L | 1.01 (0.99–1.02) | 0.455 | – |  |
Platelet, per 1 × 109/L | 1.00 (1.00–1.00) | 0.170 | – |  |
RBC, per 1 × 1012/L | 0.88 (0.77–1.01) | 0.071 | – |  |
Hemoglobin, per 1 g/L | 0.97 (0.92–1.02) | 0.196 | – |  |
AST, per 1 IU/L | 1.00 (1.00–1.00) | < 0.001 | 1.00 (1.00–1.00) | 0.128 |
ALT, per 1 IU/L | 1.00 (1.00–1.00) | 0.003 | 1.00 (1.00–1.00) | 0.382 |
Albumin, per 1 g/dL | 0.83 (0.69–0.99) | 0.041 | 0.92 (0.76–1.12) | 0.420 |
BUN, per 1 mg/dL | 1.01 (1.01–1.01) | < 0.001 | 1.01 (1.00–1.01) | 0.073 |
Creatinine, per 1 mg/dL | 1.11 (1.05–1.18) | < 0.001 | 0.92 (0.83–1.02) | 0.133 |
Bicarbonate, per 1 mmol/L | 0.96 (0.94–0.99) | 0.002 | 0.99 (0.97–1.02) | 0.666 |
pH, per 0.01 | 0.95 (0.73–1.22) | 0.663 | – |  |
BE, per 1 mmol/L | 1.00 (0.99–1.00) | 0.519 | – |  |
Glucose, per 1 mg/dL | 1.00 (1.00–1.00) | 0.182 | – |  |
Sodium, per 1 mmol/L | 1.00 (0.98–1.03) | 0.660 | – |  |
Potassium, per 1 mmol/L | 1.04 (0.93–1.18) | 0.469 | – |  |
Chloride, per 1 mmol/L | 0.99 (0.98–1.01) | 0.385 | – |  |
Calcium, per 1 mg/dL | 1.02 (0.91–1.14) | 0.707 | – |  |
Magnesium, per 1 mg/dL | 1.21 (0.99–1.49) | 0.061 | – |  |
INR, per 0.1 | 1.08 (0.99–1.17) | 0.083 | – |  |
PTT, per 1 s | 1.00 (1.00–1.00) | 0.683 | – |  |
Antiplatelet | 0.60 (0.47–0.77) | < 0.001 | 0.77 (0.58–1.01) | 0.059 |
Statins | 0.83 (0.66–1.05) | 0.117 | – |  |
Inotropes | 1.14 (0.91–1.43) | 0.267 | – |  |
Vasopressors | 1.51 (1.10–2.08) | 0.011 | 0.96 (0.67–1.38) | 0.839 |
MCS | 0.96 (0.68–1.36) | 0.829 | – |  |
CRRT | 1.73 (1.35–2.20) | < 0.001 | 1.29 (0.97–1.73) | 0.083 |
Revascularization | 0.59 (0.44–0.78) | < 0.001 | 0.81 (0.59–1.1) | 0.180 |
Mechanical ventilation | 1.09 (0.85–1.41) | 0.503 | – |  |
Glucocorticoids | 1.34 (1.07–1.67) | 0.010 | 1.42 (1.13–1.79) | 0.003 |