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Table 3 Cox regression analysis for 90-day all-cause mortality in cardiogenic shock patients before matching

From: Association between short-term systemic use of glucocorticoids and prognosis of cardiogenic shock: a retrospective analysis

 

Univariable regression

Multivariable regression

HR (95% CI)

P value

HR (95% CI)

P value

Age, per 1 year

1.03 (1.02–1.04)

< 0.001

1.03 (1.02–1.04)

< 0.001

Male

0.87 (0.74–1.02)

0.096

–

 

BMI, per 1 kg/m2

0.99 (0.98–1.00)

0.124

–

 

Charlson comorbidity index, per 1 score

1.18 (1.14–1.21)

< 0.001

1.09 (1.05–1.14)

< 0.001

SOFA, per 1 score

1.04 (1.01–1.07)

0.005

0.98 (0.95–1.01)

0.202

OASIS, per 1 score

1.05 (1.04–1.06)

< 0.001

1.00 (0.98–1.01)

0.554

APS III, per 1 score

1.02 (1.02–1.02)

< 0.001

1.01 (1.01–1.02)

< 0.001

LODS, per 1 score

1.15 (1.12–1.17)

< 0.001

1.03 (0.99–1.07)

0.194

SBP, per 1 mmHg

1.00 (0.99–1.00)

0.055

–

 

DBP, per 1 mmHg

1.00 (0.99–1.00)

0.052

–

 

Heart rate, per 1 bpm

1.01 (1.00–1.01)

0.005

1.00 (1.00–1.01)

0.200

Hypertension

0.79 (0.66–0.95)

0.013

0.87 (0.70–1.09)

0.232

Diabetes

1.12 (0.95–1.32)

0.165

–

 

Dyslipidemia

0.98 (0.84–1.15)

0.832

–

 

CKD

1.73 (1.47–2.03)

< 0.001

0.98 (0.76–1.25)

0.840

Rheumatic disease

1.07 (0.68–1.69)

0.770

–

 

Chronic pulmonary disease

1.14 (0.96–1.36)

0.125

–

 

ADHF

0.74 (0.63–0.87)

< 0.001

0.68 (0.57–0.81)

< 0.001

MI

1.22 (1.04–1.44)

0.014

1.67 (1.38–2.02)

< 0.001

Cardiac arrest

1.85 (1.51–2.28)

< 0.001

1.76 (1.41–2.21)

< 0.001

Septic shock

2.31 (1.93–2.76)

< 0.001

1.25 (1.01–1.53)

0.036

Lactate, per 1 mmol/L

1.13 (1.10–1.16)

< 0.001

1.05 (1.02–1.09)

0.001

WBC, per 1 × 109/L

1.01 (1.00–1.02)

0.131

–

 

Platelet, per 1 × 109/L

1.00 (1.00–1.00)

0.151

–

 

RBC, per 1 × 1012/L

0.78 (0.70–0.86)

< 0.001

0.96 (0.86–1.07)

0.450

Hemoglobin, per 1 g/L

0.91 (0.88–0.94)

< 0.001

–

 

AST, per 1 IU/L

1.00 (1.00–1.00)

0.210

–

 

ALT, per 1 IU/L

1.00 (1.00–1.00)

0.608

–

 

Albumin, per 1 g/dL

0.69 (0.61–0.79)

< 0.001

0.90 (0.77–1.04)

0.154

BUN, per 1 mg/dL

1.01 (1.01–1.01)

< 0.001

1.00 (1.00–1.01)

0.098

Creatinine, per 1 mg/dL

1.12 (1.07–1.17)

< 0.001

0.98 (0.91–1.06)

0.562

Bicarbonate, per 1 mmol/L

0.97 (0.96–0.99)

0.003

1.02 (1.00–1.04)

0.103

pH, per 0.01

0.84 (0.69–1.02)

0.086

–

 

BE, per 1 mmol/L

1.00 (0.99–1.00)

0.048

–

 

Glucose, per 1 mg/dL

1.00 (1.00–1.00)

0.001

1.00 (1.00–1.00)

0.426

Sodium, per 1 mmol/L

0.99 (0.98–1.01)

0.344

–

 

Potassium, per 1 mmol/L

1.11 (1.02–1.22)

0.014

1.00 (0.91–1.11)

0.971

Chloride, per 1 mmol/L

0.98 (0.97–1.00)

0.007

1.00 (0.98–1.01)

0.600

Calcium, per 1 mg/dL

1.01 (0.92–1.10)

0.906

–

 

Magnesium, per 1 mg/dL

1.22 (1.03–1.44)

0.020

1.25 (1.07–1.46)

0.005

INR, per 0.1

1.04 (0.99–1.09)

0.142

–

 

PTT, per 1 s

1.00 (1.00–1.00)

0.213

–

 

Antiplatelet

0.60 (0.50–0.72)

< 0.001

0.69 (0.55–0.86)

0.001

Statins

0.71 (0.60–0.84)

< 0.001

0.78 (0.63–0.96)

0.020

Inotropes

1.12 (0.95–1.32)

0.179

–

 

Vasopressors

1.64 (1.33–2.02)

< 0.001

1.09 (0.85–1.40)

0.483

MCS

1.30 (0.98–1.71)

0.070

–

 

CRRT

2.26 (1.87–2.73)

< 0.001

1.31 (1.04–1.65)

0.022

Revascularization

0.53 (0.43–0.64)

< 0.001

0.62 (0.49–0.78)

< 0.001

Mechanical ventilation

1.15 (0.98–1.36)

0.094

–

 

Glucocorticoids

1.93 (1.60–2.33)

< 0.001

1.48 (1.22–1.81)

< 0.001

  1. BMI Body mass index, SOFA Sequential organ failure assessment, OASIS Oxford acute severity of illness score, APS III Acute physiology score III, LODS Logistic organ dysfunction system, SBP Systolic blood pressure, DBP Diastolic blood pressure, CKD Chronic kidney disease, ADHF Acute decompensated heart failure, MI Myocardial infarction, WBC White blood cell, RBC Red blood cell, AST Aspartate aminotransferase, ALT Alanine aminotransferase, BUN Blood urea nitrogen, BE Base excess, INR International normalized ratio, PTT Partial thromboplastin time, MCS Mechanical circulatory support, CRRT Continuous renal replacement therapy, HR Hazard ratio, CI Confidence interval