| Univariable regression | Multivariable regression | ||
---|---|---|---|---|
HR (95% CI) | P value | HR (95% CI) | P value | |
Age, per 1 year | 1.03 (1.02–1.04) | < 0.001 | 1.03 (1.02–1.04) | < 0.001 |
Male | 0.87 (0.74–1.02) | 0.096 | – |  |
BMI, per 1 kg/m2 | 0.99 (0.98–1.00) | 0.124 | – |  |
Charlson comorbidity index, per 1 score | 1.18 (1.14–1.21) | < 0.001 | 1.09 (1.05–1.14) | < 0.001 |
SOFA, per 1 score | 1.04 (1.01–1.07) | 0.005 | 0.98 (0.95–1.01) | 0.202 |
OASIS, per 1 score | 1.05 (1.04–1.06) | < 0.001 | 1.00 (0.98–1.01) | 0.554 |
APS III, per 1 score | 1.02 (1.02–1.02) | < 0.001 | 1.01 (1.01–1.02) | < 0.001 |
LODS, per 1 score | 1.15 (1.12–1.17) | < 0.001 | 1.03 (0.99–1.07) | 0.194 |
SBP, per 1 mmHg | 1.00 (0.99–1.00) | 0.055 | – |  |
DBP, per 1 mmHg | 1.00 (0.99–1.00) | 0.052 | – |  |
Heart rate, per 1 bpm | 1.01 (1.00–1.01) | 0.005 | 1.00 (1.00–1.01) | 0.200 |
Hypertension | 0.79 (0.66–0.95) | 0.013 | 0.87 (0.70–1.09) | 0.232 |
Diabetes | 1.12 (0.95–1.32) | 0.165 | – |  |
Dyslipidemia | 0.98 (0.84–1.15) | 0.832 | – |  |
CKD | 1.73 (1.47–2.03) | < 0.001 | 0.98 (0.76–1.25) | 0.840 |
Rheumatic disease | 1.07 (0.68–1.69) | 0.770 | – |  |
Chronic pulmonary disease | 1.14 (0.96–1.36) | 0.125 | – |  |
ADHF | 0.74 (0.63–0.87) | < 0.001 | 0.68 (0.57–0.81) | < 0.001 |
MI | 1.22 (1.04–1.44) | 0.014 | 1.67 (1.38–2.02) | < 0.001 |
Cardiac arrest | 1.85 (1.51–2.28) | < 0.001 | 1.76 (1.41–2.21) | < 0.001 |
Septic shock | 2.31 (1.93–2.76) | < 0.001 | 1.25 (1.01–1.53) | 0.036 |
Lactate, per 1 mmol/L | 1.13 (1.10–1.16) | < 0.001 | 1.05 (1.02–1.09) | 0.001 |
WBC, per 1 × 109/L | 1.01 (1.00–1.02) | 0.131 | – |  |
Platelet, per 1 × 109/L | 1.00 (1.00–1.00) | 0.151 | – |  |
RBC, per 1 × 1012/L | 0.78 (0.70–0.86) | < 0.001 | 0.96 (0.86–1.07) | 0.450 |
Hemoglobin, per 1 g/L | 0.91 (0.88–0.94) | < 0.001 | – |  |
AST, per 1 IU/L | 1.00 (1.00–1.00) | 0.210 | – |  |
ALT, per 1 IU/L | 1.00 (1.00–1.00) | 0.608 | – |  |
Albumin, per 1 g/dL | 0.69 (0.61–0.79) | < 0.001 | 0.90 (0.77–1.04) | 0.154 |
BUN, per 1 mg/dL | 1.01 (1.01–1.01) | < 0.001 | 1.00 (1.00–1.01) | 0.098 |
Creatinine, per 1 mg/dL | 1.12 (1.07–1.17) | < 0.001 | 0.98 (0.91–1.06) | 0.562 |
Bicarbonate, per 1 mmol/L | 0.97 (0.96–0.99) | 0.003 | 1.02 (1.00–1.04) | 0.103 |
pH, per 0.01 | 0.84 (0.69–1.02) | 0.086 | – |  |
BE, per 1 mmol/L | 1.00 (0.99–1.00) | 0.048 | – |  |
Glucose, per 1 mg/dL | 1.00 (1.00–1.00) | 0.001 | 1.00 (1.00–1.00) | 0.426 |
Sodium, per 1 mmol/L | 0.99 (0.98–1.01) | 0.344 | – |  |
Potassium, per 1 mmol/L | 1.11 (1.02–1.22) | 0.014 | 1.00 (0.91–1.11) | 0.971 |
Chloride, per 1 mmol/L | 0.98 (0.97–1.00) | 0.007 | 1.00 (0.98–1.01) | 0.600 |
Calcium, per 1 mg/dL | 1.01 (0.92–1.10) | 0.906 | – |  |
Magnesium, per 1 mg/dL | 1.22 (1.03–1.44) | 0.020 | 1.25 (1.07–1.46) | 0.005 |
INR, per 0.1 | 1.04 (0.99–1.09) | 0.142 | – |  |
PTT, per 1 s | 1.00 (1.00–1.00) | 0.213 | – |  |
Antiplatelet | 0.60 (0.50–0.72) | < 0.001 | 0.69 (0.55–0.86) | 0.001 |
Statins | 0.71 (0.60–0.84) | < 0.001 | 0.78 (0.63–0.96) | 0.020 |
Inotropes | 1.12 (0.95–1.32) | 0.179 | – |  |
Vasopressors | 1.64 (1.33–2.02) | < 0.001 | 1.09 (0.85–1.40) | 0.483 |
MCS | 1.30 (0.98–1.71) | 0.070 | – |  |
CRRT | 2.26 (1.87–2.73) | < 0.001 | 1.31 (1.04–1.65) | 0.022 |
Revascularization | 0.53 (0.43–0.64) | < 0.001 | 0.62 (0.49–0.78) | < 0.001 |
Mechanical ventilation | 1.15 (0.98–1.36) | 0.094 | – |  |
Glucocorticoids | 1.93 (1.60–2.33) | < 0.001 | 1.48 (1.22–1.81) | < 0.001 |