Association between intraoperative remifentanil use and postoperative hyperalgesia in adolescent idiopathic scoliosis surgery: a retrospective study

Table 4 Weight adjusted morphine consumption at 6 hourly intervals up to 48 h

Postoperative time interval	PCA morphine usage, mg/kg [n]			P value*
Postoperative time interval	Total (N = 97)	Low dose (N = 41)	High dose (N = 56)	P value*
0–6 h	0.13 ± 0.13 0.09 (0.03–0.17) [97]	0.11 ± 0.10 0.10 (0.03–0.15) [41]	0.14 ± 0.15 0.08 (0.03–0.21) [56]	0.658
6–12 h	0.08 ± 0.07 0.06 (0.02–0.11) [97]	0.07 ± 0.07 0.05 (0.02–0.09) [41]	0.08 ± 0.07 0.06 (0.02–0.11) [56]	0.153
12–18 h	0.08 ± 0.08 0.06 (0.02–0.13) [97]	0.08 ± 0.08 0.04 (0.02–0.10) [41]	0.09 ± 0.08 0.06 (0.02–0.13) [56]	0.284
18–24 h	0.05 ± 0.07 0.04 (0-0.07) [97]	0.05 ± 0.05 0.04 (0-0.07) [41]	0.06 ± 0.07 0.04 (0-0.07) [56]	0.739
24–30 h	0.04 ± 0.05 0.02 (0-0.06) [94]	0.04 ± 0.04 0.02 (0-0.07) [41]	0.04 ± 0.06 0.02 (0-0.06) [53]	0.825
30–36 h	0.04 ± 0.05 0.02 (0-0.05) [86]	0.03 ± 0.04 0.01 (0-0.04) [37]	0.05 ± 0.06 0.02 (0-0.05) [49]	0.122
36–42 h	0.03 ± 0.05 0 (0-0.03) [45]	0.03 ± 0.06 0 (0-0.04) [23]	0.03 ± 0.05 0 (0-0.03) [22]	0.919
42–48 h	0.01 ± 0.03 0 (0-0.04) [8]	0.01 ± 0.02 0 (0-0.03) [5]	0.02 ± 0.04 0 (0-0.04) [3]	0.558
Total in 24 h	0.34 ± 0.27 0.27 (0.14–0.45) [97]	0.30 ± 0.23 0.26 (0.15–0.38) [41]	0.37 ± 0.30 0.27 (0.14–0.45) [56]	0.399
Total in 48 h	0.43 ± 0.31 0.37 (0.19–0.58) [97]	0.38 ± 0.25 0.38 (0.19–0.46) [41]	0.46 ± 0.35 0.37 (0.19–0.58) [56]	0.454

Note: Data are presented as mean ± standard deviation and median (interquartile range). The unit for remifentanil dose is µg/kg/min
^*Mann-Whitney U test

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