Skip to main content

Table 2 Risk factors of PONV using stepwise forward regression and full model (n = 205)

From: Use of sugammadex is associated with reduced incidence and severity of postoperative nausea and vomiting in adult patients with obesity undergoing laparoscopic bariatric surgery: a post-hoc analysis

Variables

Univariate

Multivariablea

Full modelb

OR (95% CI)

P value

OR (95% CI)

P value

Coefficients

OR (95% CI)

P value

Age

0.98 (0.94–1.01)

0.188

  

-0.08

0.93 (0.87–0.99)

0.015c

Female sex

2.70 (1.43–5.08)

0.002c

2.64 (1.16–6.00)

0.021c

0.94

2.55 (0.61–10.59)

0.198

BMI

0.90 (0.85–0.96)

0.001c

  

-0.01

1.00 (0.88–1.13)

0.979

ASA classification

       

 II

1

Ref

   

Ref

 

 III

5.55 (2.92–10.53)

< 0.001c

  

-0.69

0.50 (0.12–2.13)

0.349

Apfel risk score

       

 0

1

Ref

   

Ref

 

 1

1.50 (0.28–8.14)

0.638

  

0.51

1.66 (0.13–21.42)

0.699

 2

3.42 (0.70–16.76)

0.129

  

0.45

1.58 (0.08–31.69)

0.767

 3

3.21 (0.64–16.18)

0.157

  

0.33

1.38 (0.05–35.52)

0.844

 4

 N/A

> 0.999

  

43.65

 N/A

> 0.999

Diabetes mellitus

0.37 (0.20–0.70)

0.002c

0.24 (0.11–0.55)

0.001c

-0.98

0.38 (0.11–1.30)

0.123

Hypertension

0.95 (0.48–1.89)

0.893

  

0.58

1.79 (0.59–5.39)

0.301

Smoking

0.37 (0.17–0.81)

0.012c

  

-0.57

0.57 (0.11–2.95)

0.501

His_PONV

N/A

> 0.999

  

-1.06

 N/A

> 0.999

His_MS

N/A

> 0.999

  

-22.21

 N/A

> 0.999

Type of surgery

       

 LSG

1

Ref

   

Ref

 

 LSG-JJB

0.29 (0.15–0.54)

< 0.001c

  

1.39

4.02 (0.82–19.85)

0.088

 LSG-DJB

N/A

> 0.999

  

-19.28

 N/A

> 0.999

 OAGB

0.21 (0.02–1.96)

0.171

  

-18.87

 N/A

> 0.999

Dur_anesthesia

0.21 (0.09–0.49)

< 0.001c

  

-3.18

0.04 (0.01–5.62)

0.204

Dur_operation

0.23 (0.10–0.54)

0.001c

  

-4.88

0.01 (0.01–5.83)

0.150

IOC

0.94 (0.90–0.98)

0.002c

  

3.95

51.69 (0.34–7843.66)

0.124

PHC

0.68 (0.38–1.22)

0.196

  

-0.46

0.63 (0.25–1.57)

0.323

Sugammadex

0.05 (0.02–0.12)

< 0.001c

0.03 (0.01–0.09)

< 0.001c

-4.27

0.01 (0.01–0.06)

< 0.001c

Total fluid input

0.99 (0.98–1.00)

0.003c

  

-0.01

1.00 (1.00–1.00)

0.270

Rescue opioids

0.82 (0.46–1.44)

0.484

   

 N/A

 
  1. Abbreviations: ASA American Society of Anesthesiologists, BMI body mass index, CI confidence interval, Dur_anesthesia duration of the anesthesia, Dur_operation duration of the operation, His_MS history of motion sickness, His_PONV history of PONV, IOC intraoperative opioids consumption (as intravenous morphine equivalent), LSG laparoscopic sleeve gastrectomy, LSG-DJB laparoscopic sleeve gastrectomy plus duodenojejunal bypass, LSG-JJB laparoscopic sleeve gastrectomy plus jejunojejunal bypass, N/A not applicable, NMB cumulative doses of the continuous infusion of neuromuscular blockade (as intravenous cis-atracurium equivalent), OAGB one anastomosis gastric bypass, OR odds ratio, PHC penehyclidine hydrochloride administration, PONV postoperative nausea and vomiting
  2. a All variables found significantly (P < 0.1) associated with PONV by univariate analysis and clinically meaningful factors according to the prior knowledge and theory (Age, Apfel risk score, history of PONV, history of motion sickness, rescue opioids) were inserted into the multivariable logistic regression model using a forward selection strategy. Overall P value is less than 0.001 in Omnibus test of model coefficient
  3. b Overall P value is less than 0.001 in Omnibus test of model coefficient
  4. c Statistically significant (P < 0.05)