Is OPRM1 genotype a valuable predictor of VAS in patients undergoing laparoscopic radical resection of colorectal cancer with fentanyl?

Table 5 Independent effect of OPRM1 A118G polymorphism on fentanyl dose in PACU

Exposure	Non-adjusted		Adjust model I		Adjust model II
Exposure	OR(95%CI)	P Value	OR(95%CI)	P Value	OR(95%CI)	P Value
*OPRM1* A118G
GG	1.0		1.0		1.0
GA + AA	16.90 (3.78,30.03)	0.0132	13.81 (0.57,27.06)	0.0438	15.23(2.57, 27.89)	0.0205

Adjustment model I: adjusted according to age, sex, weight, height, intraoperative fentanyl dosage and operation duration
Adjustment model II: adjusted according to age, sex, weight, height, intraoperative fentanyl dosage, operation duration and the polymorphisms of CYP3A4 *1G、CYP3A5 *3, COMT Val158Met polymorphisms

ISSN: 1471-2253