Table 2 Post-operative VAS score in 48 h, intraoperative fentanyl consumption, and post-operative total morphine consumption in 48 h
Duloxetine Group (n = 30) (mean, SD) | Placebo Group (n = 30) (mean, SD) | Mean Difference (CI) | P value | |
|---|---|---|---|---|
VAS 0–2 h | 3 ± 0.69 | 4.17 ± 0.83 | -1.16 (-1.56, -0.77) | 0.01˂ |
VAS 2–4 h | 2.57 ± 0.67 | 4.30 ± 0.91 | -1.73 (-2.15, -1.31) | 0.01˂ |
VAS 4–8 h | 2.23 ± 0.77 | 3.97 ± 0.76 | -1.73 ( -2.13, -1.33) | ˂0.01 |
VAS 8–12 h | 1.63 ± 0.71 | 3.67 ± 0.84 | -2.03 ( -2.43, -1.62) | ˂0.01 |
VAS 12–24 h | 1.17 ± 0.87 | 3.70 ± 0.75 | -2.53 (-2.95, -2.11) | 0.01˂ |
VAS 24–36 h | 0.77 ± 0.77 | 3.53 ± 0.81 | -2.76 (-3.17, -2.35) | ˂0.01 |
VAS 36–48 h | 0.60 ± 0.77 | 3.50 ± 0.86 | -2.90 (-3.32, -2.47) | ˂0.01 |
Intraoperative fentanyl consumption | 25.33 ± 26.20 | 74.16 ± 27.45 | -50.8(-64.7, -36.9) | < 0.01 |
Total postoperative morphine consumption | 4.6 ± 2.9 | 11.3 ± 1.7 | -6.7 (-7.9, -5.4) | < 0.01 |