High peak inspiratory pressure may be associated with intraoperative coughing during neurosurgery under general anesthesia without neuromuscular blockade: a retrospective study

Table 3 Univarable and multivariable logistic regression analyses for intraoperative coughing

	Before propensity score matching				After propensity score matching
	Univariable logistic regression analysis		Multivariable logistic regression analysis*		Univariable logistic regression analysis		Multivariable logistic regression analysis^†
	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value	OR (95% CI)	P value
Prone position	0.34 (0.12–0.98)	0.045	0.35 (0.12–1.04)	0.058
Surgical duration (min)	1.00 (1.00-1.01)	0.033	1.00 (1.00-1.01)	0.192	1.00 (1.00-1.01)	0.047	1.01 (1.0-1.01)	0.025
PIP > 21.6 cmH₂O	3.81 (1.83–7.88)	< 0.001	3.21 (1.50–6.88)	0.003	13.81 (1.79-106.56)	0.012	14.22 (1.81-111.73)	0.012
TV/PBW (mL/kg)	1.45 (1.21–1.74)	< 0.001	1.36 (1.11–1.66)	0.003	1.34 (1.10–1.64)	0.004	1.36 (1.09–1.69)	0.006

*The adjusted variables were prone position, surgical duration, PIP > 21.6 cmH₂O, and TV/PBW. Nagelkerke R² and P value of Hosmer-Lemeshow goodness of fit test were 0.096 and 0.811, respectively. ^†The adjusted variables were surgical duration, PIP > 21.6 cmH₂O, and TV/PBW. Nagelkerke R² and P value of Hosmer-Lemeshow goodness of fit test were 0.209 and 0.950, respectively. OR, odds ratio; CI, confidence interval; PIP, peak inspiratory pressure; TV/PBW, tidal volume divided by predicted body weight

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