Table 2 GRADE evidence profile
Quality assessment | No of patients | Effect | Quality | Importance | ||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No of studies | Design | Risk of bias | Inconsistency | Indirectness | Imprecision | RIPreC | Control | Absolute (mean difference) | ||||||||||||||
Mechanical ventilation duration (overall cohort) | ||||||||||||||||||||||
12 | randomised trials | serious1 | serious2 | no serious indirectness | no serious imprecision | 596 | 654 | 5.35 h shorter (12.12 h shorter to 1.42 h longer) | ⊕ ⊕ ⃝⃝ LOW | IMPORTANT | ||||||||||||
Mechanical ventilation duration (in the absence of propofol) | ||||||||||||||||||||||
8 | randomised trials | serious3 | no serious inconsistency | no serious indirectness | no serious imprecision | 193 | 197 | 2.16 h shorter (3.87 h to 0.45 h shorter) | ⊕ ⊕ ⊕ ⃝MODERATE | IMPORTANT | ||||||||||||
ICU length of stay (overall cohort) | ||||||||||||||||||||||
12 | randomised trials | serious1 | serious4 | no serious indirectness | no serious imprecision | 630 | 683 | 11.48 h shorter (20.96 h shorter to 2.01 h shorter) | ⊕ ⊕ ⃝⃝LOW | IMPORTANT | ||||||||||||
ICU length of stay (in the absence of propofol) | ||||||||||||||||||||||
7 | randomised trials | serious3 | no serious inconsistency | no serious indirectness | no serious imprecision | 173 | 178 | 7.41 h shorter (14.77 h to 0.05 h shorter) | ⊕ ⊕ ⃝⃝ MODERATE | IMPORTANT | ||||||||||||