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Table 2 Main clinical data and laboratory tests associated with DNR in elderly patients who underwent a major thoracic surgery

From: Risk factors for delayed neurocognitive recovery in elderly patients undergoing thoracic surgery

Item

DNR(n = 26)

Non-DNR(n = 128)

P value

Preoperative blood tests

   

 Hemoglobin < 110

1(3.85%)

8(6.25%)

1.000

 Creatinine clearance (ml/min)

63.50(59.35–72.85)

65.10(56.98–78.08)

0.54

 Pre-WBC levels (× 109 /L)

4.35(3.84–5.11)

5.96(4.92–7.06)

0.02*

 Post-WBC levels (×109 /L)

12.47(9.89-17.00)

14.07(11.69–16.66)

0.243

 WBC gap

7.73(5.37–11.40)

7.92(5.45–10.52)

0.887

 NLR

1.98(1.41–2.38)

2.00(1.44–2.61)

0.771

 Hb levels

135.00(127.50-141.50)

132(125–139)

0.259

 Albumin (g/L)

40.3(38.80–43.40)

40.70(38.30–43.20)

0.871

 CRP ≥ 5

2(7.69%)

13(10.16%)

0.981

Surgical data

   

Perioperative inadvertent hypothermia(<35℃)

8(30.77%)

16(12.5%)

0.041*

Blood loss

  

0.659

 <200

23(88.46%)

117(91.41%)

 

 200–500

2(7.69%)

9(7.03%)

 

 >500

1(3.85%)

2(1.56%)

 

Hypotension(MAP < 65mmHg)

6(23.08%)

32(25.00%)

0.836

VICA(use sevoflurane ≥ 50 min)

5(19.23%)

12(9.38%)

0.144

Midazolam as a pre-anaesthetic sedative

16(61.54%)

94(73.44%)

0.221

Dexmedetomidine

21(80.77%)

113(88.28%)

0.472

Rescue analgesia

   

 Opium analgesic

10(38.46%)

56(43.75%)

0.619

 Ketorolac Tromethamine

17(65.38%)

86(67.19%)

0.859

NRS

   

 1st day after operation(resting)

  

0.792

 <4

22(84.62%)

111(86.72%)

 

 4–6

4(15.38%)

16(12.50%)

 

 >6

0

1(0.78%)

 

 1st day after operation(activity)

   

 <4

14(53.85%)

72(56.25%)

0.730

4–6

12(46.15%)

51(39.84%)

 

 >6

0

5(3.91%)

 

 1st day after operation(coughing)

  

0.364

 <4

9(34.62%)

57(44.53%)

 

 4–6

16(61.54%)

69(53.91%)

 

 >6

1(3.85%)

2(1.56%)

 

Chest tube duration ≥ 4 days

10(38.46%)

68(53.13%)

0.173

Postoperative hospital stay(days)

7(6–9)

7(6–8)

0.723

Postoperative body temperature > 38 ℃

4(15.38%)

38(29.69%)

0.135

  1. Abbreviations: DNR Delayed Neurocognitive Recovery, NRS Numeric Rating Scales, NLR Neutrophil-to-lymphocyte Ratio, VICA Intravenous inhalation combined anesthesia
  2. Continuous variables are presented as median [IQR] or mean ± SD, and categorical variables as count (%).
  3. *P < 0.05.