Fig. 11

Immunohistochemical staining for Iba-1 and glial fibrillary acidic protein (GFAP) expression in CA1 and CA3 area of hippocampus. (A) Representative microphotographs of Iba-1 and GFAP in CA1 area of hippocampal sections from the three experimental groups. Compared to the Control group and the Dex group, a higher density of Iba-1-labeled microglial and GFAP-labeled astrocyte cells were found in the model group at 3 days, but not 7 days after surgery (at × 63 magnification). (B) Representative microphotographs of Iba-1and GFAP in CA3 area of hippocampal sections from the three experimental groups. Compared to the Control group and the Dex group, a higher density of Iba-1-labeled microglial and GFAP-labeled astrocyte cells were found in the model group at 3 days, but not 7 days after surgery (at × 63 magnification) (C) GFAP expression in the CA1hippocampus of rats. (D) Iba-1 expression in the CA1 hippocampus of rats. (E) GFAP expression in the CA3 hippocampus of rats. (F) Iba-1 expression in the CA3 hippocampus of rats. N = 3 per group. Data were analyzed by one-way ANOVA with

Tukey’s multiple comparisons test. Scale bar = 20 μm. * P < 0.05 Compared with Model