Table 2 GRADE summary of findings
Outcomes | Number of patients (studies) | Effect | Certainty | Explanations | |
|---|---|---|---|---|---|
Relative(95% CI) | Absolute(95% CI) | ||||
The time first to request rescue analgesia | 330 (5 RCTs) | - | MD 8.4 higher(4.7 higher to 12.1 higher) | ⨁⨁◯◯Low | High statistical and clinical heterogeneity; unknown risk of publication bias |
The rate of rescue analgesia | 275 (4RCTs) | OR 0.33(0.17 to 0.65) | 218 fewer per 1,000(from 295 to 97 fewer) | ⨁⨁⨁◯ Moderate | Unknown risk of publication bias |
The number of PCIA presses | 233 (3RCTs) | - | MD 5.79 lower(7.24 lower to 4.35 lower) | ⨁⨁◯◯ Low | High statistical and clinical heterogeneity; unknown risk of publication bias |
The rate of PONV | 450 (7RCTs) | OR 0.57(0.36 to 0.91) | 96 fewer per 1,000(from 153 to 18 fewer) | ⨁⨁⨁◯ Moderate | Unknown risk of publication bias |
The incidence of hypotension | 283 (4RCTs) | OR 1.01(0.37 to 2.74) | 1 more per 1,000(from 40 fewer to 94 more) | ⨁⨁⨁◯ Moderate | Unknown risk of publication bias |
The rate of arrhythmia | 283 (4RCTs | OR 0.76(0.19 to 3.07) | 26 fewer per 1,000(from 95 fewer to 176 more) | ⨁⨁◯◯ Low | High statistical and clinical heterogeneity; unknown risk of publication bias |