Table 1 Liver function tests measured at t0 in Wild Type patients, and patients with CYP3A5 rs776746 A/G and UGT1A1 rs8330 C/G genotypes. Median, IqR

Aspartate transaminase, IU/L

47.50 [32.75–97.25]

61.00 [48.00–61.00]

52.00 [30.75–83.75]

Alanine transaminase, IU/L

40.00 [22.25–99.00]

36.00 [25.00–36.00]

40.50 [27.50–71.75]

Lactate dehydrogenase, IU/L

285.50 [211.50–385.75]

252.00 [187.00–252.00]

248.50 [219.50–343.50]

International Normalized Ratio, AU

1.31 [1.22–1.40]

1.29 [1.26–1.34]

1.26 [1.20–1.48]

Bilirubin, mg/dL

0.80 [0.65–1.70]

1.30 [0.95–2.15]

1.35 [0.60–2.60]