| Overall (n = 328) | Low Tidal Volume (n = 158) | Conventional Tidal Volume (n = 170) | Unadjusted Analysis | Adjusted Analysis* | ||
---|---|---|---|---|---|---|---|
Absolute Difference (95% CI) | p value | Absolute Difference (95% CI) | p value | ||||
PPC within 7 days | 124 / 326 (38.0) | 52 / 157 (33.1) | 72 / 169 (42.6) | −9.48 (− 19.86 to 1.05)a | 0.076 | −10.36 (− 20.52 to − 0.20)a | 0.046 |
 Pneumonia | 12 / 327 (3.7) | 6 / 158 (3.8) | 6 / 169 (3.6) | 0.25 (− 4.02 to 4.64)a | 0.906 | 0.12 (−3.98 to 4.22)a | 0.954 |
 Respiratory failure | 54 / 327 (16.5) | 21 / 158 (13.3) | 33 / 169 (19.5) | −6.24 (−14.26 to 1.81)a | 0.126 | −6.71 (− 14.66 to 1.25)a | 0.098 |
 Pleural effusion | 31 / 326 (9.5) | 15 / 158 (9.5) | 16 / 168 (9.5) | − 0.03 (− 6.48 to 6.49)a | 0.993 | −0.31 (−6.61 to 5.99)a | 0.924 |
 Atelectasis | 84 / 327 (25.7) | 36 / 157 (22.9) | 48 / 170 (28.2) | −5.31 (−14.70 to 4.18)a | 0.270 | −6.09 (−15.40 to 3.23)a | 0.199 |
 Pneumothorax | 0 / 327 (0.0) | 0 / 158 (0.0) | 0 / 169 (0.0) | – | – | – | – |
 Bronchospasm | 5 / 327 (1.5) | 2 / 158 (1.3) | 3 / 169 (1.8) | −0.51 (−3.57 to 2.48)a | 0.706 | − 0.51 (− 3.20 to 2.19)a | 0.711 |
 Pulmonary congestion | 6 / 327 (1.8) | 2 / 158 (1.3) | 4 / 169 (2.4) | −1.10 (−4.43 to 2.02)a | 0.454 | −1.20 (− 4.14 to 1.75)a | 0.424 |
 Unplanned NIV or IMV | 7 / 327 (2.1) | 3 / 158 (1.9) | 4 / 169 (2.4) | −0.47 (−3.93 to 2.98)a | 0.769 | −0.43 (−3.55 to 2.69)a | 0.786 |
PPC during hospital stay | 128 / 324 (39.5) | 53 / 157 (33.8) | 75 / 167 (44.9) | −11.15 (−21.60 to −0.52)a | 0.039 | − 12.13 (− 22.35 to − 1.91)a | 0.020 |
Pulmonary embolism | 2 / 324 (0.6) | 1 / 158 (0.6) | 1 / 166 (0.6) | 0.03 (−2.16 to 2.31)a | 0.972 | 0.07 (−1.63 to 1.77)a | 0.933 |
Acute respiratory distress syndrome | 0 / 324 (0.0) | 0 / 158 (0.0) | 0 / 166 (0.0) | – | – | – | – |
SIRS | 1 / 326 (0.3) | 0 / 157 (0.0) | 1 / 169 (0.6) | −0.60 (−1.80 to 0.62)a | 0.336 | −0.58 (−1.78 to 0.63)a | 0.347 |
Sepsis | 11 / 327 (3.4) | 7 / 158 (4.4) | 4 / 169 (2.4) | 2.06 (−1.92 to 6.45)a | 0.305 | 2.22 (−1.72 to 6.16)a | 0.269 |
Acute kidney injury | 24 / 228 (10.5) | 11 / 115 (9.6) | 13 / 113 (11.5) | −1.94 (− 10.14 to 6.15)a | 0.633 | − 1.60 (−9.61 to 6.42)a | 0.695 |
 Risk | 18 / 228 (7.9) | 8 / 115 (7.0) | 10 / 113 (8.8) |  |  |  |  |
 Injury | 1 / 228 (0.4) | 1 / 115 (0.9) | 0 / 113 (0.0) |  |  |  |  |
 Failure | 5 / 228 (2.2) | 2 / 115 (1.7) | 3 / 113 (2.7) |  |  |  |  |
Wound infection | 6 / 325 (1.8) | 3 / 158 (1.9) | 3 / 167 (1.8) | 0.10 (−3.13 to 3.44)a | 0.945 | −0.09 (−3.00 to 2.83)a | 0.952 |
Intraoperative need of vasopressor | 269 / 322 (83.5) | 130 / 156 (83.3) | 139 / 166 (83.7) | −0.40 (−8.59 to 7.72)a | 0.923 | −0.80 (−8.85 to 7.25)a | 0.845 |
Unplanned ICU admission | 15 / 320 (4.7) | 8 / 155 (5.2) | 7 / 165 (4.2) | 0.92 (−3.85 to 5.87)a | 0.698 | 1.03 (−3.62 to 5.69)a | 0.663 |
Need for MET call | 26 / 327 (8.0) | 12 / 158 (7.6) | 14 / 169 (8.3) | −0.69 (−6.66 to 5.33)a | 0.818 | −0.78 (−6.62 to 5.06)a | 0.793 |
Length of stay | |||||||
 In ICU (hours) | 27.3 ± 33.6 | 29.4 ± 31.8 | 26.0 ± 35.1 | 3.36 (−15.09 to 21.82)b | 0.716 | 6.51 (−12.04 to 25.06)b | 0.484 |
 Median (IQR) | 15 (13 to 27) | 17 (12 to 28) | 15 (13 to 20) | ||||
 In hospital (days) | 6.7 ± 6.0 | 7.0 ± 6.4 | 6.4 ± 5.7 | 0.64 (−0.66 to 1.96)b | 0.333 | 0.54 (−0.72 to 1.81)b | 0.399 |
 Median (IQR) | 5 (3 to 8) | 5 (3 to 8) | 4 (3 to 7) | ||||
In-hospital mortality | 5 / 328 (1.5) | 3 / 158 (1.9) | 2 / 170 (1.2) | 0.72 (−1.95 to 3.39)a | 0.595 | 0.78 (− 1.86 to 3.42)a | 0.562 |