Table 2 Hemodynamic and metabolic relative (d, %) and absolute changes (Δ) after fluid bolus (FB), baseline ratio of veno-arterial carbon dioxide difference to arterio-venous oxygen difference ratio (PvaCO2/CavO2): low group has PvaCO2/CavO2 < 1.4, and high group has PvaCO2/CavO2 ≥ 1.4 mmHg/mL. Variables are expressed as the median (25–75% percentiles)
| Â | Low Group | High Group | p values |
|---|---|---|---|
No of patients | 13 | 27 | Â |
d Hemoglobin (%) | -8.1 (-10.9 − -5.9) | -9.3 (-12.1 − -4.6) | 0.97 |
Δ Hemoglobin (mg/dL) | -1.0 (-1.2 − -0.6) | -1.0 (-1.3 − -0.5) | 0.94 |
Metabolic variables changes | |||
 Δ ScvO2 (%) | -0.6 (-2.4 − 4.2) | 1.8 (-3.6 − 3.8) | 0.89 |
 d Lactate (%) | -4.8 (-14.2 − 2.7) | 9.2 (-3.1 − 16.6) | 0.01 |
 Δ Lactate (mmol/L) | -0.13 (-0.31 − 0.04) | 0.26 (-0.11 − 0.52) | 0.01 |
 d PvaCO2 (%) | 43 (24 − 118) | -27 (-42 − -2) |  < 0.01 |
 Δ PvaCO2 (mmHg) | 2.6 (0.9 − 4.7) | -2.41 (-3.95 − -0.21) |  < 0.01 |
 d PvaCO2/ CavO2 (%) | 98 (41 − 139) | -15 (-34 − -2) |  < 0.01 |
 Δ PvaCO2/ CavO2 (mmHg/mL) | 0.92 (0.35 − 1.08) | -0.31 (-0.71 − -0.04) |  < 0.01 |
 d Oxygen delivery (%) | 0.3 (-6.9 − 9.5) | 4.5 (-7.3 − 14.5) | 0.49 |
 Δ Oxygen delivery (mL/min/m2) | 1.39 (-19.6 − 27.3) | 22.42 (-30.53 − 53.34) | 0.58 |
 d Oxygen consumption (%) | -1.6 (-5.6 − 1.9) | 3.9 (-3.8 − 19.7) | 0.11 |
 Δ Oxygen consumption (mL/min/m2) | 0.92 ( -4.32 − 3.14) | 4.08 (-5.53 − 18.95) | 0.34 |
 Δ Oxygen extraction (%) | -0.54 (-3.61 − 3.33) | -1.1 (-3.13 − 2.12) | 0.95 |
Hemodynamic variables changes | |||
 d Cardiac Index (%) | 8.8 (2.9 − 17.4) | 13.4 (8.3 − 20.2) | 0.34 |
 Δ Cardiac Index (L/min/m2) | 0.21 (0.06 − 0.43) | 0.45 (0.21 − 0.54) | 0.11 |
 d Stroke Volume (%) | 12.4 (0.47 − 15.5) | 17 (5.5 − 22.4) | 0.07 |
 Δ Stroke Volume (mL) | 5.16 (0.13 − 9.56) | 10.23 (2.28 − 13.33) | 0.14 |
 d Heart rate (%) | -0.9 (-3.2 − 2.3) | -1.7 (-6.1 − 6.3) | 0.73 |
 Δ Heart rate (beats/min) | -1 (-3 − 2) | -2 (-6 − 3) | 0.75 |
 d Pulse Pressure (%) | 6.3 (-1.4 − 15.1) | 17.5 (-4.1 − 46.8) | 0.32 |
 Δ Pulse Pressure (mmHg) | 2 (-1 − 5) | 9 (-3 − 27) | 0.24 |
 d Mean Arterial Pressure (%) | 1.7 (-7.7 − 13.6) | 7.7 (-4.3 − 24.6) | 0.21 |
 Δ Mean Arterial Pressure (mmHg) | 1 (-6 − 11) | 6 (-4 − 19) | 0.26 |
 d Central Venous Pressure (%) | 28 (12 − 143) | 27 (10 − 62) | 0.92 |
 Δ Central Venous Pressure (mmHg) | 2 (1 − 4) | 2 (1 − 4) | 0.96 |