Fig. 7

The combination of atipamezole with caffeine dramatically accelerated emergence from a simulated pediatric MRI sedation procedure. The same group of 8 rats were exposed to two sedation sessions, a week apart. At the end of one session the rats received a bolus injection of saline and in the other atipamezole (6 µg/kg) with caffeine (25 mg/kg). The order of the drug injections was randomized. Rats were placed on their backs in a waking box, and the time for the rats to recover their righting reflex was recorded. This time is plotted in the figure as the emergence time. The figure plots the time to emerge from sedation for rats receiving saline (leftmost group) or the same rats receiving atipamezole with caffeine (rightmost group). There was ~ 93% decrease in Emergence Time. The difference was significant (p = 0.0001; paired t-test). RORR Times (in seconds): Saline (control): 1170, 1948, 1769, 3947, 2244, 2880, 3211, 3361, Atipamezole (6 μg/kg) with Caffeine (25 mg/kg): 75, 12, 12, 77, 280, 165, 522, 275