Table 2 Secondary outcomes

Nauseas and vomiting

4 [23, 26, 28, 29]

16/185 (8.65%)

23/185 (12.43%)

66

0.89 [0.21, 3.69]

0.87

Agitation

3 [26, 28, 29]

16/155 (10.32%)

11/155 (7.10%)

0

1.45 [0.71, 2.94]

0.30

Oxygen saturation below 90%

1 [18]

0/10 (0.00%)

2/10 (20.00%)

-

-

-

Secondary outcomes

Number of studies (Reference no.)

Number of patients in Midazolam group

Number of patients in Ketamine group

I² (%)

Standardized Mean difference with [95% CI]

P value

Onset of sedation

3 [15, 21, 22]

80

86

0

-0.59 [-0.90, -0.28]

0.0002*

Recovery time

3 [22, 24, 28]

86

87

82

-1.06 [-1.83, -0.28]

0.008*

Heart rate (HR)

4 [21, 24,25,26]

152

151

96

-1.39 [-2.84, 0.06]

0.06

Systolic blood pressure (SBP)

1 [21]

32

32

-

-

-

Mean blood pressure (MBP)

2 [24, 25]

50

50

0

-0.53 [-0.93, -0.13]

0.009*

Oxygen saturation

2 [21, 24]

62

62

57

-0.57 [-1.13, -0.02]

0.04*