Sedative effect and safety of different doses of S-ketamine in combination with propofol during gastro-duodenoscopy in school-aged children: a prospective, randomized study

Table 2 Sedation related conditions

	Group P (n = 30)	Group S_0.3 (n = 29)	Group S_0.5 (n = 30)	Group S_0.7 (n = 30)	P value
Number of cases with smooth placement of first endoscope insertion	5	10	15	25	-
Smooth placement rate of first endoscope insertion (%)	16.70 (5.64 -34.72)	34.50 (17.94 -54.33)^†	50.00 (31.30 -68.70)^†	83.30 (65.28 -94.36)^†‡SS	< 0.001
Times of additional propofol	2.50 (1.00–3.00)	2.00 (1.00–2.00)^†	2.00 (1.00–2.00)^†	1.00 (0.00–1.25)^†	< 0.001
Total amount of propofol (mg.kg⁻¹)	5.66 (4.28–6.97)	4.32 (3.87–4.94)	4.41 (3.92–4.88)	3.94 (3.00–4.30)^†	0.003
Recovery time (min)	28.70 ± 15.66	29.45 ± 11.40	33.50 ± 16.47	35.67 ± 19.04	0.280
PACU stay (min)	45.27 ± 16.21	57.55 ± 15.59	58.53 ± 24.07	60.63 ± 23.74^†	0.018
Endoscopist satisfaction rate	7.00 (6.00–7.00)	7.00 (7.00–8.50)	8.00 (7.00–10.00)^†	9.00 (8.00–9.00)^†‡	< 0.001

Data are expressed as rate (95% confidence interval), median (interquartile range) or mean ± standard deviation, as appropriate
PACU Post anesthesia care unit
^†P < 0.05 vs. Group P; ^‡ P < 0.05 vs. Group S_0.3. ^SS P < 0.05 vs. Group S_0.5

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