Comparison of onset time, duration of action, and intubating conditions after cisatracurium 0.15 mg/kg in young and elderly patients

Table 2 Intraoperative data including onset time and duration of action for cisatracurium 0.15 mg/kg in young and elderly patients

	Young	Elderly	Difference with 95%CI	P-value
n	31	29
Onset time, seconds Time to TOF 0	199 (59)	297 (120)	98 (49 to 147)	< 0.001
Duration of action, minutes Time to TOF 0.9	77 (14) n = 24	89 (17) n = 26	12 (2.5 to 20.5)	0.01
Time used for intubation, seconds^a	92 (74)	115 (157)	23 (−86 to 40)	0.46
Duration of anesthesia, minutes	188 (137)	189 (67)	–	–
Duration of surgery, minutes	118 (123)	108 (57)	–	–
Administration of supplemental cisatracurium after intubation	2 (6%)	1 (3%)
Administration of neostigmine	5 (17%)	1 (3%)
Administration of ephedrine or phenylephrine before TOF 0	0	12 (43%)
Type of surgery			–	–
Plastic/breast	24	19
Orthopedic	7	10
Use of inhalational anesthesia during surgery	1 (3%)	0	–	–

Data presented as count and frequencies (%) or mean and standard deviation (SD)
In seven patients the duration of action was not determined due to administration of neostigmine, administration of supplemental doses of cistracurium or monitoring difficulties
^aFrom taking the laryngoscope until tracheal intubation verified by capnography

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