Parameter | All (N = 6282) | SvO2 ≥ 60% at admission + at 4 h (N = 4585) | SvO2 ≥ 60% at admission, < 60% at 4 h (N = 746) | SvO2 < 60% at admission, ≥ 60% at 4 h (N = 403) | SvO2 < 60% at admission + at 4 h (N = 528) | P |
---|---|---|---|---|---|---|
CI on admission (L/min/m2) | 2.36 (2.03–2.77) | 2.43 (2.09–2.83) | 2.35 (2.0–2.72) | 2.09 (1.8–2.39) | 2.04 (1.73–2.36) | < 0.001 |
CI at 4 h (L/min/m2) | 2.47 (2.15–2.84) | 2.55 (2.23–2.92) | 2.28 (2.0–2.59) | 2.39 (2.12–2.74) | 2.11 (1.87–2.42) | < 0.001 |
HB on admission (g/L) | 105 (96–114) | 106 (98–115) | 101 (94–110) | 101 (91–111) | 99 (91–108) | < 0.001 |
HB at 4 h (g/L) | 102 (94–112) | 104 (95–114) | 98 (90–107) | 99 (90–107) | 95 (86–102) | < 0.001 |
Lactate on admission (mmol/L) | 1.4 (1.1–1.8) | 1.3 (1.1–1.7) | 1.4 (1.1–1.8) | 1.6 (1.2–2.3) | 1.8 (1.4–2.7) | < 0.001 |
Lactate at 4 h (mmol/L) | 1.3 (1.0–1.8) | 1.3 (1.0–1.7) | 1.5 (1.2–2.0) | 1.5 (1.1–2.1) | 1.8 (1.4–2.7) | < 0.001 |
P/F ratio on admission | 38 (29–48) | 39 (30–49) | 36 (28–45) | 34 (23–44) | 32 (22–43) | < 0.001 |
P/F ratio at 4 h | 40 (30–48) | 41 (32–49) | 39 (29–48) | 37 (27–47) | 33 (25–42) | < 0.001 |
SpO2 on admission (%) | 97 (95–99) | 97 (95–99) | 97 (94–98) | 96 (93–98) | 96 (92–98) | < 0.001 |
SpO2 at 4 h (%) | 97 (96–99) | 98 (96–99) | 97 (96–99) | 98 (96–99) | 98 (96–99) | 0.007 |
PaO2 on admission (kPa) | 15.6 (12.7–19.4) | 15.9 (12.9–19.7) | 15.3 (12.8–19.0) | 14.5 (11.1–17.8) | 14.2 (11.5–18.9) | < 0.001 |
PaO2 at 4 h (kPa) | 15.2 (12.7–18.2) | 15.5 (12.9–18.4) | 14.1 (11.4 (17.1) | 15.4 (12.8–19.3) | 14.5 (11.9–17.7) | < 0.001 |
Fluids 0–4 h (mL) | 1500 (1050–2200) | 1450 (950–2000) | 1700 (1300–2400) | 1650 (1150–2400) | 2000 (1400–2750) | < 0.001 |
Red blood cell transfusions 0–4 h (units) | 1 (1–1) | 1 (1–1) | 1 (1–1) | 1 (1–1) | 1 (1–1) | 0.67 |
Max VIS category 0–4 h, % (n) | ||||||
0–5 | 16.7 (528) | 18.7 (859) | 12.7 (95) | 14.6 (59) | 5.7 (30) | < 0.001 |
5–15 | 29.3 (1838) | 30.6 (1402) | 26.7 (199) | 27.6 (111) | 23.9 (126) | < 0.001 |
15–30 | 12.8 (804) | 12.1 (556) | 12.9 (96) | 16.4 (66) | 16.3 (86) | < 0.001 |
30–45 | 2.7 (172) | 2.4 (112) | 3.1 (23) | 3.2 (13) | 4.5 (24) | < 0.001 |
>45 | 38.4 (2405) | 36.1 (1656) | 44.6 (333) | 38.2 (154) | 49.6 (262) | < 0.001 |