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Table 4 Secondary endpoints

From: The efficacy and safety of an adapted opioid-free anesthesia regimen versus conventional general anesthesia in gynecological surgery for low-resource settings: a randomized pilot study

Variable

OFA group

N = 18 (%)

CGA group

N = 18 (%)

RR

95% CI

p – value

Mean time between the end of maintenance anesthesia and extubation in minutes (SD)

13.61 ± 6.55

17.67 ± 6.25

-

-

0.0705

Median time between the end of maintenance anesthesia and extubation in minutes

11

18.5

-

-

0.0705

Need of morphine for postoperative pain relief

0

6

2.5

1.61–3.89

0.0095

Need of oxygen postoperatively

1 (5.6%)

12 (66.7%)

12

1.74–82.89

 < 0.001

Need of reintubation

0 (0%)

0 (0%)

-

-

-

Postoperative ileus

1 (5.6%)

15 (83.3%)

15

2.21–101.9

 < 0.001

Mean hours for return of intestinal transit (SD)

15.7 ± 5.5

71 ± 25

55.3

43.04–67.56

 < 0.001

Median hours for return of intestinal transit

17

74

-

-

 < 0.001

Postoperative nausea and vomiting

2 (11.1%)

9 (50%)

4.5

1.13–17.99

0.0137

Mean hour of occurrence of PONV (SD)

2.0 ± 0.0

1.6 ± 0.69

-

-

0.3961

Mean hour of occurrence of PONV

2.0

2.0

-

-

0.3961

Pruritus

0 (0%)

6 (33.3%)

-

-

0.0095

Mean time between the end of surgery and the first walk in hours (SD)

10.44 ± 3.60

21.94 ± 9.48

11.5

6.64 – 16.36

 < 0.001

Median time between the end of surgery and the first walk in hours

10

24

-

-

 < 0.001

Postoperative satisfaction at the 48th hour (mean QoR-40 score)

179.72 ± 8.70

(good satisfaction)

84.11 ± 42.71

(Moderate satisfaction)

-

-

 < 0.001

Mean length of hospital stay in days (SD)

5.06 ± 0.42

5.22 ± 0.65

-

-

0.4328

Median length of hospital stay in days

5

5

-

-

0.4328

Mean total cost of drugs used for anesthesia (XAF)

46,500 ± 2,573

57,000 ± 5,379

-

-

 < 0.001

  1. CGA Conventional general anesthesia, CI Confidence interval, PONV Postoperative nausea and vomiting, OFA Opioid-free anesthesia, RR Risk ratio, SaO2 Oxygen peripheral saturation, QoR-40 Quality of Rehabilitation, SD Standard deviation