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Table 3 Analysis of risk factors for POD

From: Lower preoperative serum uric acid level may be a risk factor for postoperative delirium in older patients undergoing hip fracture surgery: a matched retrospective case-control study

 

Univariate analysis

Multivariate analysis

Case (n=48)

Control (n=48)

p value

aOR (95% CI)

p value

BMI, (kg/m2)

 Underweight

6 (12.50)

2 (4.17)

.312

  

 Normal

23 (47.92)

23 (47.92)

Ref

  

 Overweight

12 (25.00)

20 (41.67)

.292

  

 Obesity

7 (14.58)

3 (6.25)

.270

  

Medical history, n (%)

 Diabetes mellitus

12 (25.00)

11 (22.92)

.808

  

 Hypertension

32 (66.67)

30 (62.50)

.566

  

 Cerebrovascular disease

15 (31.25)

6 (12.50)

.039

1.594 (0.454-5.596)

.467

 CAD

20 (41.67)

13 (27.08)

.134

1.734 (0.457-6.577)

.419

Pre. Labo data

 Cr, mg/dL

63.00 (50.00,83.00)

62.00 (52.25,76.75)

.463

  

 BUN, mg/dL

7.20 (4.93,9.08)

6.65 (4.80,8.48)

.297

  

 Log preoperative SUAa

2.33 ± 0.16

2.42 ± 0.13

.015

0.028 (0.001-0.844)

.040

 ALT, U/L

12.50 (9.00,16.00)

10.00 (8.00,18.50)

.651

  

 AST, U/L

17.00 (14.25,20.75)

18.00 (15.25,23.00)

.829

  

Intraoperative medications, n (%)

 Dexmedetomidine

35 (72.92)

37 (77.08)

.638

  

 Midazolam

1 (2.08)

2 (4.17)

.571

  

 Droperidol

2 (4.17)

1 (2.08)

.571

  

 Butorphanol

6 (12.50)

7 (14.58)

.782

  

 Dexamethasone

11 (22.92)

13 (27.08)

.655

  

 Dynastat

3 (6.25)

5 (10.42)

.484

  

 Dezocine

2 (4.17)

6 (12.50)

.178

0.525 (0.058-4.771)

.567

Intraoperative factors

 Infusion volume, mL

800.0 (700.0,1000.0)

800. 0 (600.0,1000.0)

.091

1.002 (0.999-1.005)

.186

 Hemorrhage volume, mL

200.0 (112.5,200.0)

200.0 (118.8,222.5)

.728

  

 Urine output, mL

200.0 (100.0,275.0)

175.0 (100.0,200.0)

.245

  

 Duration of anesthesia, min

65.50 (52.25,79.25)

57.00 (50.25,70.50)

.483

  

 Duration of surgery, min

116.21 ± 26.59

112.88 ± 23.28

.062

1.034 (1.004-1.065)

.024

Blood RT

 ESR, mm/h

36.75 ± 20.54

35.00 ± 17.29

.649

  

 NLR

5.24 (3.27,8.34)

3.94 (2.70,5.30)

.007

1.314 (1.053-1.638)

.015

 Hb, g/dL

101.94 ± 18.28

106.98 ± 23.02

.269

  

 CRP, mg/L

61.10 (46.22,97.72)

63.92 (38.12,94.43)

.292

  

 ALB, g/L

35.91 ± 3.81

36.80 ± 3.75

.217

  

 Cys C, mg/L

0.78 (0.58,0.99)

0.80 (0.65,1.06)

.695

  

 Blood glucose, mmol/L

5.98 (5.07,7.18)

5.64 (5.14,6.97)

.730

  

Other risk factors

 Electrolyte disorder, n (%)

21 (43.75)

18 (37.50)

.549

  
  1. aLevels of preoperative SUA were normalized by log10 transformation
  2. Data are presented as number (%), means (standard deviations), or medians (interquartile range). Abbreviations: ALB Albumin, ALT Alanine transaminases, AST Aspartate aminotransferases, aOR Adjusted odds ratio, Blood RT Blood routine test, BMI Body Mass Index, BUN Blood urea nitrogen, CAD Coronary artery disease, CI Confidence interval, CRP C-reactive protein, Cr Creatinine, Cys C Cystatin C, ESR Erythrocyte sedimentation rate, Hb Hemoglobin, NLR Neutrophil-to-lymphocyte ratio, SUA Serum uric acid