Skip to main content
Fig. 6 | BMC Anesthesiology

Fig. 6

From: Fentanyl activates ovarian cancer and alleviates chemotherapy-induced toxicity via opioid receptor-dependent activation of EGFR

Fig. 6

Fentanyl activates ovarian cancer cells via stimulating EGFR and in an opioid receptor-dependent manner. A Western blot of EGFR in SK-OV-3 cells after si-EGFR knockdown. EGFR depletion significantly reverses the effects of fentanyl in increasing proliferation (B) and migration (C) in SK-OV-3 cells. D Western blot of p-EGFR and EGFR in SK-OV-3 cells after in the presence of naloxone and fentanyl alone, or both. The blots were cut prior to hybridization with antibodies during blotting. Naloxone (10 μM) completely reverses the effects of fentanyl in increasing proliferation (E) and migration (F) in SK-OV-3 cells. *, p < 0.01, compared to control

Back to article page

BMC Anesthesiology

ISSN: 1471-2253

Contact us