Fig. 4

Second Study Cohort: Circulating eNAMPT levels are significantly elevated in Sepsis and ARDS subjects compared to healthy controls. In Panel A Y-axis represents eNAMPT Log 2 transformed values; X-axis group comparison: healthy controls (green), ARDS (red), Sepsis (yellow). Median plasma eNAMPT values were significantly higher in ARDS and Sepsis compared to healthy controls—3.78 ng/ml, 4.7 ng/ml, and 1.2 ng/ml respectively; p < 0.01. B ROC Curve. Plasma eNAMPT levels accurately distinguished healthy controls from ARDS (red), AUC 0.85 (95% CI 0.8–0.9, p-value < 0.0001), and healthy controls from Sepsis (yellow), AUC 0.87 (95% IC 0.82–0.92 p-value < 0.0001). No significant differences between ARDS and Sepsis