Fig. 3

First Study Cohort: Circulating eNAMPT are elevated in ARDS, Sepsis, and Trauma subjects compared to healthy controls. Data represented in Panels A and B reflect eNAMPT measurements in plasma samples and Panels C and D reflect eNAMPT measurements in serum samples. In Panels A and C, the Y-axis represents eNAMPT Log 2 transformed values; X-axis group comparison: healthy controls (green), ARDS (red), Sepsis (yellow or brown), and Trauma (blue). B ROC plot and the corresponding AUC show that eNAMPT (at baseline) distinguishes: i) ARDS (red) from healthy controls (AUC = 0.86, 95% confidence interval: 0.82–0.90, p-value < 0.001); ii) sepsis (yellow) from healthy controls (AUC = 0.89, 95% confidence interval: 0.85–0.93 p < 0.001) and iii) trauma (blue) vs healthy controls (AUC = 0.94, 95% confidence interval: 0.90–0.97 p < 0.001. D ROC plot and AUC of eNAMPT in serum of septic subjects, AUC 0.88, 95% CI 0.81–0.95, p < 0.01