Fig. 2

First Study Cohort: Pancreatitis circulating eNAMPT levels are significantly elevated in acute pancreatitis compared to controls. Positive correlation with disease severity. A Y-axis represents log base 2 transformation of plasma eNAMPT values; X-axis group comparison: healthy controls and pancreatitis by severity groups – mild, moderate, severe. Comparisons of medians between pancreatitis and healthy controls and pancreatitis by severity subgroups significantly differ (p-value < 0.01) Kruskal–Wallis test. eNAMPT levels were significantly different in the three severity categories of acute pancreatitis, with significantly higher levels in severe pancreatitis compared to mild pancreatitis, (median 67.7 vs 17.6 ng/ml, p < 0.01).B Pancreatitis ROC plots and the corresponding AUCs. eNAMPT distinguishes acute pancreatitis from healthy subjects (blue) (AUC = 0.74, 95% confidence interval: 0.62–0.86, p 0.009). High diagnostic accuracy for eNAMPT levels was observed in patients with severe (red) pancreatitis compared to mild (brown) pancreatitis (AUC = 0.92, 95% confidence interval: 0.85—1.0, p-value < 0.01)