Association between fluid intake and extubation failure in intensive care unit patients with negative fluid balance: a retrospective observational study

Table 3 Adjusted ORs for extubation failure using FB and fluid intake as design variables

Model 1 (Negative FB)			Model 2 (Fluid intake)
Variables	OR [95% CI]	P value	Variables	OR [95% CI]	P value
Negative FB categories			Fluid intake categories
< −40 ml/kg	1.07 [0.62, 1.75]	0.806	< 30 ml/kg	0.75 [0.54, 1.05]	0.088
-40 to −20 ml/kg	0.87 [0.61, 1.22]	0.431	30 to 60 ml/kg	Reference
-20 to 0 ml/kg	Reference		> 60 ml/kg	1.63 [0.73, 3.35]	0.206
MV duration (per 24 hours increase)	1.05 [1.01, 1.09]	0.016	MV duration (per 24 hours increase)	1.05 [1.01, 1.09]	0.022
COPD (Yes vs No)	1.43 [1.03, 1.97]	0.031	COPD (Yes vs No)	1.48 [1.06, 2.04]	0.019
RSBI (per 10 units increase)	1.06 [1.00, 1.13]	0.052	RSBI (per 10 units increase)	1.06 [1.00, 1.13]	0.055
PaCO₂ before extubation			PaCO₂ before extubation
< 35 mmHg	0.99 [0.60, 1.58]	0.962	< 35 mmHg	0.99 [0.60, 1.58]	0.959
35–45 mmHg	Reference		35–45 mmHg	Reference
> 45 mmHg	1.66 [1.17, 2.35]	0.004	> 45 mmHg	1.73 [1.22, 2.45]	0.002
Missing	0.54 [0.28, 1.00]	0.057	Missing	0.56 [0.29, 1.02]	0.073
SAPS II	1.01 [1.00, 1.02]	0.046	SAPS II	1.01 [1.00, 1.02]	0.043
Diuretics (Yes vs No)	1.59 [1.17, 2.15]	0.003	Diuretics (Yes vs No)	1.64 [1.21, 2.23]	0.001

OR odds ratio, FB fluid balance, MV mechanical ventilation, COPD chronic obstructive pulmonary disease, RSBI rapid shallow breathing index, SAPS II simplified acute physiology score
Model 1 evaluated the association between negative fluid balance and extubation failure, with MV duration, COPD, RSBI, PaCO₂, SAPS II, and diuretics use as confounders. Model 2 evaluated the association between fluid intake and extubation failure, with MV duration, COPD, RSBI, PaCO₂, SAPS II, and diuretics use as confounders

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